MiMeDB: Showing metabocard for Folic acid (MMDBc0000032)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-10-27 23:27:53 UTC

Update Date

2024-09-27 22:51:55 UTC

Metabolite ID

MMDBc0000032

Metabolite Identification

Common Name

Folic acid

Description

Folic acid is a member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid, being biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylated tRNA, and generate and use formate. Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia. Folic acid is also a microbial metabolite produced by Bifidobacterium and Lactobacillus (PMID: 22254078 ).

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

158
  Mrv1652305271900122D          

 32 34  0  0  1  0            999 V2000
   12.8598    0.2286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9988    1.0426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1501   -1.0116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.8502    2.7036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4213    2.6981    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5220   -0.2286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7180   -0.1921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1504   -1.4434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9740   -1.0250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5220   -2.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9740   -2.7322    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075   -1.4661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0930   -2.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4309    0.2231    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   11.4277    1.0481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1406    1.4634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0019    0.2176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2890   -0.1977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1469   -0.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8633   -1.0282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4343   -1.0337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2922   -1.0227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5730    0.2121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5793   -1.4379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601   -0.2032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7214   -1.4490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1374    2.2883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2364   -1.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2364   -2.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7214   -2.3083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5220   -1.0536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075   -2.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 19  1  0  0  0  0
  2 17  2  0  0  0  0
  3 19  2  0  0  0  0
  4 27  1  0  0  0  0
  5 27  2  0  0  0  0
  6 31  2  0  0  0  0
 14  7  1  1  0  0  0
  7 17  1  0  0  0  0
  8 20  1  0  0  0  0
  8 21  1  0  0  0  0
  9 26  1  0  0  0  0
  9 28  2  0  0  0  0
 10 29  1  0  0  0  0
 10 32  1  0  0  0  0
 11 29  2  0  0  0  0
 11 30  1  0  0  0  0
 12 31  1  0  0  0  0
 12 32  2  0  0  0  0
 13 32  1  0  0  0  0
 14 15  1  0  0  0  0
 14 19  1  0  0  0  0
 15 16  1  0  0  0  0
 16 27  1  0  0  0  0
 17 18  1  0  0  0  0
 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 20 24  2  0  0  0  0
 20 25  1  0  0  0  0
 21 26  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 26 30  2  0  0  0  0
 28 29  1  0  0  0  0
 28 31  1  0  0  0  0
M  END

HMDB0000121
     RDKit          3D
Folic acid
 51 53  0  0  0  0  0  0  0  0999 V2000
   10.4116   -1.4536    0.4273 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0241   -1.2491    0.2534 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1885   -2.3168    0.0716 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8709   -2.1420   -0.0963 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1061   -3.1171   -0.2620 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3039   -0.8781   -0.0928 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9925   -0.6790   -0.2606 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4934    0.5884   -0.2498 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0128    0.7870   -0.4637 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2460    0.4249    0.6919 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8307    0.4016    0.6170 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0418    0.0095    1.6744 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3261   -0.0293    1.5686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9974    0.3242    0.3876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4503    0.2448    0.3255 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0451   -0.4496    1.1747 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1532    0.9342   -0.6703 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6241    0.8388   -0.7155 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.9198   -0.5491   -1.1390 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3177   -1.0072   -1.2308 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9998   -1.1219    0.0523 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3984   -1.0017    1.1364 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.3779   -1.3757    0.0516 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1937    1.3884    0.4876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5640    1.5441    1.5446 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5482    1.7902    0.4873 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2012    0.7160   -0.6615 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1868    0.7578   -0.5586 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3357    1.6593   -0.0657 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6533    1.4714    0.1039 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1381    0.2051    0.0896 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4537   -0.0373    0.2530 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7824   -1.6825    1.3573 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.0461   -1.3738   -0.3823 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7825    0.1388   -1.3628 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075    1.8327   -0.7739 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7240    0.1859    1.5737 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5424   -0.2588    2.5797 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9309   -0.3311    2.3864 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6279    1.5107   -1.3811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8771    1.5599   -1.5989 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2775   -1.2611   -0.5577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4695   -0.6372   -2.1978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9247   -0.3188   -1.8981 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3356   -1.9989   -1.7758 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7184   -2.3352   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7636    2.7675    0.5882 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6797    0.9959   -1.5835 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7788    1.0742   -1.4098 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8932    2.6567   -0.0627 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.0750    0.7969    0.3921 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 18 24  1  0
 24 25  2  0
 24 26  1  0
 14 27  1  0
 27 28  2  0
  8 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32  2  1  0
 31  6  1  0
 28 11  1  0
  1 33  1  0
  1 34  1  0
  9 35  1  0
  9 36  1  0
 10 37  1  0
 12 38  1  0
 13 39  1  0
 17 40  1  0
 18 41  1  6
 19 42  1  0
 19 43  1  0
 20 44  1  0
 20 45  1  0
 23 46  1  0
 26 47  1  0
 27 48  1  0
 28 49  1  0
 29 50  1  0
 32 51  1  0
M  END

158
  Mrv1652305271900122D          

 32 34  0  0  1  0            999 V2000
   12.8598    0.2286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.9988    1.0426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1501   -1.0116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.8502    2.7036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4213    2.6981    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5220   -0.2286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7180   -0.1921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1504   -1.4434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9740   -1.0250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5220   -2.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9740   -2.7322    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075   -1.4661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0930   -2.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4309    0.2231    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   11.4277    1.0481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1406    1.4634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0019    0.2176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2890   -0.1977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1469   -0.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8633   -1.0282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4343   -1.0337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2922   -1.0227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5730    0.2121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5793   -1.4379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8601   -0.2032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7214   -1.4490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1374    2.2883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2364   -1.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2364   -2.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7214   -2.3083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5220   -1.0536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075   -2.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 19  1  0  0  0  0
  2 17  2  0  0  0  0
  3 19  2  0  0  0  0
  4 27  1  0  0  0  0
  5 27  2  0  0  0  0
  6 31  2  0  0  0  0
 14  7  1  1  0  0  0
  7 17  1  0  0  0  0
  8 20  1  0  0  0  0
  8 21  1  0  0  0  0
  9 26  1  0  0  0  0
  9 28  2  0  0  0  0
 10 29  1  0  0  0  0
 10 32  1  0  0  0  0
 11 29  2  0  0  0  0
 11 30  1  0  0  0  0
 12 31  1  0  0  0  0
 12 32  2  0  0  0  0
 13 32  1  0  0  0  0
 14 15  1  0  0  0  0
 14 19  1  0  0  0  0
 15 16  1  0  0  0  0
 16 27  1  0  0  0  0
 17 18  1  0  0  0  0
 18 22  2  0  0  0  0
 18 23  1  0  0  0  0
 20 24  2  0  0  0  0
 20 25  1  0  0  0  0
 21 26  1  0  0  0  0
 22 24  1  0  0  0  0
 23 25  2  0  0  0  0
 26 30  2  0  0  0  0
 28 29  1  0  0  0  0
 28 31  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000032

> <DATABASE_NAME>
MIME

> <SMILES>
NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1

> <INCHI_IDENTIFIER>
InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

> <INCHI_KEY>
OVBPIULPVIDEAO-LBPRGKRZSA-N

> <FORMULA>
C19H19N7O6

> <MOLECULAR_WEIGHT>
441.3975

> <EXACT_MASS>
441.139681375

> <JCHEM_ACCEPTOR_COUNT>
12

> <JCHEM_ATOM_COUNT>
51

> <JCHEM_AVERAGE_POLARIZABILITY>
42.056565993428265

> <JCHEM_BIOAVAILABILITY>
0

> <JCHEM_DONOR_COUNT>
6

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

> <ALOGPS_LOGP>
-0.04

> <JCHEM_LOGP>
-0.682200202289524

> <ALOGPS_LOGS>
-3.76

> <JCHEM_MDDR_LIKE_RULE>
1

> <JCHEM_NUMBER_OF_RINGS>
3

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-2

> <JCHEM_PKA>
4.173198454797142

> <JCHEM_PKA_STRONGEST_ACIDIC>
3.3738517754186743

> <JCHEM_PKA_STRONGEST_BASIC>
2.086519926687477

> <JCHEM_POLAR_SURFACE_AREA>
208.99000000000004

> <JCHEM_REFRACTIVITY>
111.01120000000002

> <JCHEM_ROTATABLE_BOND_COUNT>
9

> <JCHEM_RULE_OF_FIVE>
0

> <ALOGPS_SOLUBILITY>
7.61e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
folate

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0000121
     RDKit          3D
Folic acid
 51 53  0  0  0  0  0  0  0  0999 V2000
   10.4116   -1.4536    0.4273 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0241   -1.2491    0.2534 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1885   -2.3168    0.0716 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8709   -2.1420   -0.0963 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1061   -3.1171   -0.2620 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3039   -0.8781   -0.0928 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9925   -0.6790   -0.2606 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4934    0.5884   -0.2498 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0128    0.7870   -0.4637 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2460    0.4249    0.6919 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8307    0.4016    0.6170 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0418    0.0095    1.6744 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3261   -0.0293    1.5686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9974    0.3242    0.3876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4503    0.2448    0.3255 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0451   -0.4496    1.1747 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1532    0.9342   -0.6703 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6241    0.8388   -0.7155 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.9198   -0.5491   -1.1390 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3177   -1.0072   -1.2308 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9998   -1.1219    0.0523 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3984   -1.0017    1.1364 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.3779   -1.3757    0.0516 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1937    1.3884    0.4876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5640    1.5441    1.5446 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5482    1.7902    0.4873 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2012    0.7160   -0.6615 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1868    0.7578   -0.5586 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3357    1.6593   -0.0657 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6533    1.4714    0.1039 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1381    0.2051    0.0896 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4537   -0.0373    0.2530 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7824   -1.6825    1.3573 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.0461   -1.3738   -0.3823 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7825    0.1388   -1.3628 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075    1.8327   -0.7739 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7240    0.1859    1.5737 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5424   -0.2588    2.5797 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9309   -0.3311    2.3864 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6279    1.5107   -1.3811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8771    1.5599   -1.5989 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2775   -1.2611   -0.5577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4695   -0.6372   -2.1978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9247   -0.3188   -1.8981 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3356   -1.9989   -1.7758 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7184   -2.3352   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7636    2.7675    0.5882 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6797    0.9959   -1.5835 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7788    1.0742   -1.4098 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8932    2.6567   -0.0627 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.0750    0.7969    0.3921 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 18 24  1  0
 24 25  2  0
 24 26  1  0
 14 27  1  0
 27 28  2  0
  8 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32  2  1  0
 31  6  1  0
 28 11  1  0
  1 33  1  0
  1 34  1  0
  9 35  1  0
  9 36  1  0
 10 37  1  0
 12 38  1  0
 13 39  1  0
 17 40  1  0
 18 41  1  6
 19 42  1  0
 19 43  1  0
 20 44  1  0
 20 45  1  0
 23 46  1  0
 26 47  1  0
 27 48  1  0
 28 49  1  0
 29 50  1  0
 32 51  1  0
M  END

HEADER    PROTEIN                                 27-MAY-19   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 158                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-MAY-19         0                                  
HETATM    1  O   UNK     0      24.005   0.427   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      18.664   1.946   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      22.680  -1.888   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      23.987   5.047   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      21.320   5.036   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0       6.574  -0.427   0.000  0.00  0.00           O+0
HETATM    7  N   UNK     0      20.007  -0.359   0.000  0.00  0.00           N+0
HETATM    8  N   UNK     0      13.347  -2.694   0.000  0.00  0.00           N+0
HETATM    9  N   UNK     0       9.285  -1.913   0.000  0.00  0.00           N+0
HETATM   10  N   UNK     0       6.574  -5.047   0.000  0.00  0.00           N+0
HETATM   11  N   UNK     0       9.285  -5.100   0.000  0.00  0.00           N+0
HETATM   12  N   UNK     0       5.241  -2.737   0.000  0.00  0.00           N+0
HETATM   13  N   UNK     0       3.907  -5.047   0.000  0.00  0.00           N+0
HETATM   14  C   UNK     0      21.338   0.416   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0      21.332   1.956   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0      22.662   2.732   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0      18.670   0.406   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0      17.339  -0.369   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0      22.674  -0.348   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0      14.678  -1.919   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0      12.011  -1.930   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0      17.345  -1.909   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0      16.003   0.396   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0      16.015  -2.684   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0      14.672  -0.379   0.000  0.00  0.00           C+0
HETATM   26  C   UNK     0      10.680  -2.705   0.000  0.00  0.00           C+0
HETATM   27  C   UNK     0      22.656   4.271   0.000  0.00  0.00           C+0
HETATM   28  C   UNK     0       7.908  -2.737   0.000  0.00  0.00           C+0
HETATM   29  C   UNK     0       7.908  -4.277   0.000  0.00  0.00           C+0
HETATM   30  C   UNK     0      10.680  -4.309   0.000  0.00  0.00           C+0
HETATM   31  C   UNK     0       6.574  -1.967   0.000  0.00  0.00           C+0
HETATM   32  C   UNK     0       5.241  -4.277   0.000  0.00  0.00           C+0
CONECT    1   19                                                            
CONECT    2   17                                                            
CONECT    3   19                                                            
CONECT    4   27                                                            
CONECT    5   27                                                            
CONECT    6   31                                                            
CONECT    7   14   17                                                       
CONECT    8   20   21                                                       
CONECT    9   26   28                                                       
CONECT   10   29   32                                                       
CONECT   11   29   30                                                       
CONECT   12   31   32                                                       
CONECT   13   32                                                            
CONECT   14    7   15   19                                                  
CONECT   15   14   16                                                       
CONECT   16   15   27                                                       
CONECT   17    2    7   18                                                  
CONECT   18   17   22   23                                                  
CONECT   19    1    3   14                                                  
CONECT   20    8   24   25                                                  
CONECT   21    8   26                                                       
CONECT   22   18   24                                                       
CONECT   23   18   25                                                       
CONECT   24   20   22                                                       
CONECT   25   20   23                                                       
CONECT   26    9   21   30                                                  
CONECT   27    4    5   16                                                  
CONECT   28    9   29   31                                                  
CONECT   29   10   11   28                                                  
CONECT   30   11   26                                                       
CONECT   31    6   12   28                                                  
CONECT   32   10   12   13                                                  
MASTER        0    0    0    0    0    0    0    0   32    0   68    0
END

COMPND    HMDB0000121
HETATM    1  N1  UNL     1      10.412  -1.454   0.427  1.00  0.00           N  
HETATM    2  C1  UNL     1       9.024  -1.249   0.253  1.00  0.00           C  
HETATM    3  N2  UNL     1       8.188  -2.317   0.072  1.00  0.00           N  
HETATM    4  C2  UNL     1       6.871  -2.142  -0.096  1.00  0.00           C  
HETATM    5  O1  UNL     1       6.106  -3.117  -0.262  1.00  0.00           O  
HETATM    6  C3  UNL     1       6.304  -0.878  -0.093  1.00  0.00           C  
HETATM    7  N3  UNL     1       4.992  -0.679  -0.261  1.00  0.00           N  
HETATM    8  C4  UNL     1       4.493   0.588  -0.250  1.00  0.00           C  
HETATM    9  C5  UNL     1       3.013   0.787  -0.464  1.00  0.00           C  
HETATM   10  N4  UNL     1       2.246   0.425   0.692  1.00  0.00           N  
HETATM   11  C6  UNL     1       0.831   0.402   0.617  1.00  0.00           C  
HETATM   12  C7  UNL     1       0.042   0.009   1.674  1.00  0.00           C  
HETATM   13  C8  UNL     1      -1.326  -0.029   1.569  1.00  0.00           C  
HETATM   14  C9  UNL     1      -1.997   0.324   0.388  1.00  0.00           C  
HETATM   15  C10 UNL     1      -3.450   0.245   0.325  1.00  0.00           C  
HETATM   16  O2  UNL     1      -4.045  -0.450   1.175  1.00  0.00           O  
HETATM   17  N5  UNL     1      -4.153   0.934  -0.670  1.00  0.00           N  
HETATM   18  C11 UNL     1      -5.624   0.839  -0.715  1.00  0.00           C  
HETATM   19  C12 UNL     1      -5.920  -0.549  -1.139  1.00  0.00           C  
HETATM   20  C13 UNL     1      -7.318  -1.007  -1.231  1.00  0.00           C  
HETATM   21  C14 UNL     1      -8.000  -1.122   0.052  1.00  0.00           C  
HETATM   22  O3  UNL     1      -7.398  -1.002   1.136  1.00  0.00           O  
HETATM   23  O4  UNL     1      -9.378  -1.376   0.052  1.00  0.00           O  
HETATM   24  C15 UNL     1      -6.194   1.388   0.488  1.00  0.00           C  
HETATM   25  O5  UNL     1      -5.564   1.544   1.545  1.00  0.00           O  
HETATM   26  O6  UNL     1      -7.548   1.790   0.487  1.00  0.00           O  
HETATM   27  C16 UNL     1      -1.201   0.716  -0.662  1.00  0.00           C  
HETATM   28  C17 UNL     1       0.187   0.758  -0.559  1.00  0.00           C  
HETATM   29  C18 UNL     1       5.336   1.659  -0.066  1.00  0.00           C  
HETATM   30  N6  UNL     1       6.653   1.471   0.104  1.00  0.00           N  
HETATM   31  C19 UNL     1       7.138   0.205   0.090  1.00  0.00           C  
HETATM   32  N7  UNL     1       8.454  -0.037   0.253  1.00  0.00           N  
HETATM   33  H1  UNL     1      10.782  -1.683   1.357  1.00  0.00           H  
HETATM   34  H2  UNL     1      11.046  -1.374  -0.382  1.00  0.00           H  
HETATM   35  H3  UNL     1       2.783   0.139  -1.363  1.00  0.00           H  
HETATM   36  H4  UNL     1       2.808   1.833  -0.774  1.00  0.00           H  
HETATM   37  H5  UNL     1       2.724   0.186   1.574  1.00  0.00           H  
HETATM   38  H6  UNL     1       0.542  -0.259   2.580  1.00  0.00           H  
HETATM   39  H7  UNL     1      -1.931  -0.331   2.386  1.00  0.00           H  
HETATM   40  H8  UNL     1      -3.628   1.511  -1.381  1.00  0.00           H  
HETATM   41  H9  UNL     1      -5.877   1.560  -1.599  1.00  0.00           H  
HETATM   42  H10 UNL     1      -5.278  -1.261  -0.558  1.00  0.00           H  
HETATM   43  H11 UNL     1      -5.470  -0.637  -2.198  1.00  0.00           H  
HETATM   44  H12 UNL     1      -7.925  -0.319  -1.898  1.00  0.00           H  
HETATM   45  H13 UNL     1      -7.336  -1.999  -1.776  1.00  0.00           H  
HETATM   46  H14 UNL     1      -9.718  -2.335  -0.070  1.00  0.00           H  
HETATM   47  H15 UNL     1      -7.764   2.767   0.588  1.00  0.00           H  
HETATM   48  H16 UNL     1      -1.680   0.996  -1.583  1.00  0.00           H  
HETATM   49  H17 UNL     1       0.779   1.074  -1.410  1.00  0.00           H  
HETATM   50  H18 UNL     1       4.893   2.657  -0.063  1.00  0.00           H  
HETATM   51  H19 UNL     1       9.075   0.797   0.392  1.00  0.00           H  
CONECT    1    2   33   34
CONECT    2    3    3   32
CONECT    3    4
CONECT    4    5    5    6
CONECT    6    7    7   31
CONECT    7    8
CONECT    8    9   29   29
CONECT    9   10   35   36
CONECT   10   11   37
CONECT   11   12   12   28
CONECT   12   13   38
CONECT   13   14   14   39
CONECT   14   15   27
CONECT   15   16   16   17
CONECT   17   18   40
CONECT   18   19   24   41
CONECT   19   20   42   43
CONECT   20   21   44   45
CONECT   21   22   22   23
CONECT   23   46
CONECT   24   25   25   26
CONECT   26   47
CONECT   27   28   28   48
CONECT   28   49
CONECT   29   30   50
CONECT   30   31   31
CONECT   31   32
CONECT   32   51
END

HMDB0000121
     RDKit          3D
Folic acid
 51 53  0  0  0  0  0  0  0  0999 V2000
   10.4116   -1.4536    0.4273 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0241   -1.2491    0.2534 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1885   -2.3168    0.0716 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8709   -2.1420   -0.0963 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1061   -3.1171   -0.2620 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3039   -0.8781   -0.0928 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9925   -0.6790   -0.2606 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4934    0.5884   -0.2498 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0128    0.7870   -0.4637 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2460    0.4249    0.6919 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8307    0.4016    0.6170 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0418    0.0095    1.6744 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3261   -0.0293    1.5686 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9974    0.3242    0.3876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4503    0.2448    0.3255 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0451   -0.4496    1.1747 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1532    0.9342   -0.6703 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6241    0.8388   -0.7155 C   0  0  1  0  0  0  0  0  0  0  0  0
   -5.9198   -0.5491   -1.1390 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3177   -1.0072   -1.2308 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9998   -1.1219    0.0523 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3984   -1.0017    1.1364 O   0  0  0  0  0  0  0  0  0  0  0  0
   -9.3779   -1.3757    0.0516 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1937    1.3884    0.4876 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5640    1.5441    1.5446 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5482    1.7902    0.4873 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2012    0.7160   -0.6615 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1868    0.7578   -0.5586 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3357    1.6593   -0.0657 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6533    1.4714    0.1039 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1381    0.2051    0.0896 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4537   -0.0373    0.2530 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7824   -1.6825    1.3573 H   0  0  0  0  0  0  0  0  0  0  0  0
   11.0461   -1.3738   -0.3823 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7825    0.1388   -1.3628 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8075    1.8327   -0.7739 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7240    0.1859    1.5737 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5424   -0.2588    2.5797 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9309   -0.3311    2.3864 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6279    1.5107   -1.3811 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8771    1.5599   -1.5989 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2775   -1.2611   -0.5577 H   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4695   -0.6372   -2.1978 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9247   -0.3188   -1.8981 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3356   -1.9989   -1.7758 H   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7184   -2.3352   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7636    2.7675    0.5882 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6797    0.9959   -1.5835 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.7788    1.0742   -1.4098 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.8932    2.6567   -0.0627 H   0  0  0  0  0  0  0  0  0  0  0  0
    9.0750    0.7969    0.3921 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  2  0
  3  4  1  0
  4  5  2  0
  4  6  1  0
  6  7  2  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  1  0
 11 12  2  0
 12 13  1  0
 13 14  2  0
 14 15  1  0
 15 16  2  0
 15 17  1  0
 17 18  1  0
 18 19  1  0
 19 20  1  0
 20 21  1  0
 21 22  2  0
 21 23  1  0
 18 24  1  0
 24 25  2  0
 24 26  1  0
 14 27  1  0
 27 28  2  0
  8 29  2  0
 29 30  1  0
 30 31  2  0
 31 32  1  0
 32  2  1  0
 31  6  1  0
 28 11  1  0
  1 33  1  0
  1 34  1  0
  9 35  1  0
  9 36  1  0
 10 37  1  0
 12 38  1  0
 13 39  1  0
 17 40  1  0
 18 41  1  6
 19 42  1  0
 19 43  1  0
 20 44  1  0
 20 45  1  0
 23 46  1  0
 26 47  1  0
 27 48  1  0
 28 49  1  0
 29 50  1  0
 32 51  1  0
M  END

Synonyms

Value	Source
Folate	ChEBI
Folsaeure	ChEBI
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid	ChEBI
N-Pteroyl-L-glutamic acid	ChEBI
PGA	ChEBI
PteGlu	ChEBI
Pteroyl-L-glutamic acid	ChEBI
Pteroyl-L-monoglutamic acid	ChEBI
Pteroylglutamic acid	ChEBI
Vitamin BC	ChEBI
Vitamin m	ChEBI
Folicet	Kegg
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamate	Generator
N-Pteroyl-L-glutamate	Generator
Pteroyl-L-glutamate	Generator
Pteroyl-L-monoglutamate	Generator
Pteroylglutamate	Generator
Acifolic	HMDB
Cytofol	HMDB
Dosfolat b activ	HMDB
Folacid	HMDB
Folacin	HMDB
Folbal	HMDB
Folcidin	HMDB
Foldine	HMDB
Folettes	HMDB
Foliamin	HMDB
Folipac	HMDB
Folsan	HMDB
Folsaure	HMDB
Folsav	HMDB
Folvite	HMDB
Incafolic	HMDB
Liver lactobacillus casei factor	HMDB
Millafol	HMDB
N-(4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid	HMDB
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid	HMDB
Pteroylmonoglutamic acid	HMDB
Vitamin be	HMDB
Folic acid, (DL)-isomer	HMDB
Folic acid, sodium salt	HMDB
Folic acid, (D)-isomer	HMDB
Folic acid, monosodium salt	HMDB
Folic acid, potassium salt	HMDB
b9, Vitamin	HMDB
Folic acid, calcium salt (1:1)	HMDB
Folic acid, monopotassium salt	HMDB
Vitamin b9	HMDB

Molecular Formula

C₁₉H₁₉N₇O₆

Average Mass

441.3975

Monoisotopic Mass

441.139681375

IUPAC Name

(2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid

Traditional Name

folate

CAS Registry Number

59-30-3

SMILES

NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1

InChI Identifier

InChI=1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1

InChI Key

OVBPIULPVIDEAO-LBPRGKRZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as methoxyphenols. Methoxyphenols are compounds containing a methoxy group attached to the benzene ring of a phenol moiety.

Kingdom

Super Class

Class

Sub Class

Direct Parent

Alternative Parents

Substituents

Methoxyphenol
Phenoxy compound
Anisole
Methoxybenzene
Phenol ether
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Monocyclic benzene moiety
Carboxylic acid derivative
Monocarboxylic acid or derivatives
Ether
Carboxylic acid
Organic oxygen compound
Organooxygen compound
Carbonyl group
Hydrocarbon derivative
Organic oxide
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

monocarboxylic acid (CHEBI:545959 )
phenols (CHEBI:545959 )
monomethoxybenzene (CHEBI:545959 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.076 g/L	ALOGPS
logP	-0.04	ALOGPS
logP	-0.68	ChemAxon
logS	-3.8	ALOGPS
pKa (Strongest Acidic)	3.37	ChemAxon
pKa (Strongest Basic)	2.09	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	12	ChemAxon
Hydrogen Donor Count	6	ChemAxon
Polar Surface Area	208.99 Å²	ChemAxon
Rotatable Bond Count	9	ChemAxon
Refractivity	111.01 m³·mol⁻¹	ChemAxon
Polarizability	42.06 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Extracellular

Biospecimen Locations

Blood
Brain
Cellular Cytoplasm
Cerebrospinal Fluid (CSF)
Erythrocyte
Feces
Kidney
Liver
Urine

Tissue Locations

Brain
Erythrocyte
Kidney
Liver

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0191859	Methylenetetrahydrofolate reductase	Unknown	P42898	Homo sapiens
MMDBp0192070	Glycine N-methyltransferase	Unknown	Q14749	Homo sapiens
MMDBp0192325	Formimidoyltransferase-cyclodeaminase	Enzyme	O95954	Homo sapiens
MMDBp0192410	Dihydrofolate reductase	Enzyme	P00374	Homo sapiens
MMDBp0192979	5-formyltetrahydrofolate cyclo-ligase	Unknown	P49914	Homo sapiens
MMDBp0193099	Cytochrome P450 2E1	Unknown	P05181	Homo sapiens
MMDBp0193395	Canalicular multispecific organic anion transporter 2	Transporter	O15438	Homo sapiens
MMDBp0193475	ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	Homo sapiens
MMDBp0193496	Folate receptor alpha	Enzyme	P15328	Homo sapiens
MMDBp0193550	Folate transporter 1	Enzyme	P41440	Homo sapiens
MMDBp0193615	Thiamine transporter 1	Enzyme	O60779	Homo sapiens
MMDBp0193790	Proton-coupled folate transporter	Transporter	Q96NT5	Homo sapiens
MMDBp0193851	Folate receptor gamma	Enzyme	P41439	Homo sapiens
MMDBp0193878	Gamma-glutamyl hydrolase	Enzyme	Q92820	Homo sapiens
MMDBp0193945	Multidrug resistance-associated protein 4	Transporter	O15439	Homo sapiens
MMDBp0194161	Dihydrofolate reductase	Enzyme	B0YJ76	Homo sapiens
MMDBp0194757	Solute carrier family 22 member 6	Transporter	Q4U2R8	Homo sapiens
MMDBp0194875	ATP-binding cassette sub-family C member 11	Transporter	Q96J66	Homo sapiens
MMDBp0196382	Folate receptor beta	Unknown	P14207	Homo sapiens
MMDBp0196383	Mitochondrial folate transporter/carrier	Transporter	Q9H2D1	Homo sapiens
MMDBp0196384	Folate transporter-like protein C2orf83	Unknown	Q53S99	Homo sapiens
MMDBp0196385	Probable folate receptor delta	Unknown	A6ND01	Homo sapiens
MMDBp0196796	Dihydrofolate reductase, mitochondrial	Unknown	Q86XF0

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference
MMDBr0018067	Dihydrofolic acid	Folic acid	Dihydrofolate reductase	Reduction	PathBank	31602464
MMDBr0018750	Folic acid	Tetrahydrofolic acid	Dihydrofolate reductase	Reduction	PathBank	31602464
MMDBr0019770	Dihydrofolic acid	Folic acid	Dihydrofolate reductase	Reduction	PathBank	31602464
MMDBr0019772	Folic acid	Tetrahydrofolic acid	Dihydrofolate reductase	Reduction	PathBank	31602464

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Alzheimer's disease	Decreased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	11959400
Alzheimer's disease	Increased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	21474939
Dimethylglycine dehydrogenase deficiency		Association	Human Blood	HMDB	10102904
Fibromyalgia	Increased	Association	Human Cerebrospinal Fluid (CSF)	HMDB	20087382
Rheumatoid arthritis	Slight Increase	Association	Human Blood	HMDB	16277678

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota	Apicomplexa	1		Microbial culture
Bacteria/Eubacteria	Firmicutes	544	Human ; Human feces; Human saliva; Human supragingival plaque; Human subgingival plaque; Human mucosa; Human pleural fluid plaque; Human urine; Human sputum; Pig ; Cattle ; Human stool	Microbial culture; Metabolic reconstruction
Eukaryota	Euglenozoa	1		Microbial culture
Bacteria/Eubacteria	Spirochaetes	4	Human feces	Microbial culture; Metabolic reconstruction
Bacteria/Eubacteria	Tenericutes	9	Human feces	Microbial culture; Metabolic reconstruction
Bacteria/Eubacteria	Actinobacteria	198	Human ; Human feces; Human saliva; Human mucosa; Human supragingival plaque; Human stool; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human subgingival plaque	Microbial culture; Metabolic reconstruction
Bacteria/Eubacteria	Proteobacteria	224	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool; Human sputum; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab	Microbial culture; Metabolic reconstruction
Bacteria	Actinobacteria	26	Human ; Human feces; Human saliva; Human mucosa; Human supragingival plaque; Human stool; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human subgingival plaque	Microbial culture; Metabolic reconstruction
Bacteria/Eubacteria	Verrucomicrobia	1	Human ; Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Bacteroidetes	160	Human feces; Human appendix biopsy; Human ; Human stool; Human saliva; Human gastric fluid; Human urine; Human subgingival plaque; Human supragingival plaque	Metabolic reconstruction
Bacteria	Firmicutes	35	Human ; Human feces; Human saliva; Human supragingival plaque; Human subgingival plaque; Human mucosa; Human pleural fluid plaque; Human urine; Human sputum; Pig ; Cattle ; Human stool	Microbial culture; Metabolic reconstruction
Bacteria	Proteobacteria	9	Human ; Human feces; Human feces; pleural fluid plaque; bal; Human stool; Human sputum; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab	Microbial culture; Metabolic reconstruction
Archaea	Thaumarchaeota	2		Metabolic reconstruction
Bacteria/Eubacteria	Fusobacteria	25	Human feces; Human	Metabolic reconstruction
Bacteria/Eubacteria	Synergistetes	4	Human feces	Metabolic reconstruction
Archaea	Euryarchaeota	8		Metabolic reconstruction
Bacteria/Eubacteria	Planctomycetes	1	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	2		Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	1	Human feces; Human saliva	Unknown

Exposure Sources

Food Exposures

Source Type	Source Sub-type	Source Name	Data Source	Reference
Animal	Not Available	African ostrich	FooDB	34893796
Animal	Not Available	Agar	FooDB	DTU
Animal	Not Available	American butterfish	FooDB	34893796
Animal	Not Available	American lobster	FooDB	34893796
Animal	Not Available	American shad	FooDB	34893796
Animal	Not Available	Anchovy	FooDB	34893796
Animal	Not Available	Anguilliformes	FooDB	DTU
Animal	Not Available	Atlantic cod	FooDB	34893796
Animal	Not Available	Atlantic croaker	FooDB	34893796
Animal	Not Available	Atlantic halibut	FooDB	DTU
Animal	Not Available	Atlantic herring	FooDB	34893796
Animal	Not Available	Atlantic pollock	FooDB	34893796
Animal	Not Available	Atlantic salmon	FooDB	34893796
Animal	Not Available	Atlantic wolffish	FooDB	DTU
Animal	Not Available	Blue crab	FooDB	34893796
Animal	Not Available	Blue mussel	FooDB	34893796
Animal	Not Available	Bluefish	FooDB	34893796
Animal	Not Available	Burbot	FooDB	DTU
Animal	Not Available	Carp bream	FooDB	DTU
Animal	Not Available	Catfish	FooDB	34893796
Animal	Not Available	Channel catfish	FooDB	34893796
Animal	Not Available	Charr	FooDB	DTU
Animal	Not Available	Chicken	FooDB	DTU
Animal	Not Available	Chinook salmon	FooDB	34893796
Animal	Not Available	Chum salmon	FooDB	34893796
Animal	Not Available	Cichlidae (tilapia)	FooDB	34893796
Animal	Not Available	Cisco	FooDB	34893796
Animal	Not Available	Clawed lobster	FooDB	DTU
Animal	Not Available	Clupeinae (herring, sardine, sprat)	FooDB	DTU
Animal	Not Available	Coho salmon	FooDB	34893796
Animal	Not Available	Common carp	FooDB	34893796
Animal	Not Available	Common dab	FooDB	DTU
Animal	Not Available	Common ling	FooDB	34893796
Animal	Not Available	Common octopus	FooDB	DTU
Animal	Not Available	Conch	FooDB	34893796
Animal	Not Available	Cow	FooDB	34893796
Animal	Not Available	Crab	FooDB	DTU
Animal	Not Available	Crayfish	FooDB	DTU
Animal	Not Available	Cusk	FooDB	34893796
Animal	Not Available	Cuttlefish	FooDB	34893796
Animal	Not Available	Domestic goat	FooDB	34893796
Animal	Not Available	Dungeness crab	FooDB	34893796
Animal	Not Available	Eastern oyster	FooDB	34893796
Animal	Not Available	European anchovy	FooDB	34893796
Animal	Not Available	Flatfish	FooDB	DTU
Animal	Not Available	Florida pompano	FooDB	34893796
Animal	Not Available	Freshwater drum	FooDB	34893796
Animal	Not Available	Freshwater eel	FooDB	34893796
Animal	Not Available	Gadiformes	FooDB	DTU
Animal	Not Available	Gadus (common cod)	FooDB	DTU
Animal	Not Available	Garfish	FooDB	DTU
Animal	Not Available	Greater sturgeon	FooDB	34893796
Animal	Not Available	Greenland halibut/turbot	FooDB	DTU
Animal	Not Available	Grouper	FooDB	34893796
Animal	Not Available	Haddock	FooDB	DTU
Animal	Not Available	Hippoglossus (common halibut)	FooDB	34893796
Animal	Not Available	Irish moss	FooDB	34893796
Animal	Not Available	Japanese sea bass	FooDB	34893796
Animal	Not Available	Kelp	FooDB	34893796
Animal	Not Available	King mackerel	FooDB	34893796
Animal	Not Available	Kombu	FooDB	DTU
Animal	Not Available	Lake trout	FooDB	DTU
Animal	Not Available	Laver	FooDB	34893796
Animal	Not Available	Lemon sole	FooDB	DTU
Animal	Not Available	Lingcod	FooDB	34893796
Animal	Not Available	Lumpsucker	FooDB	DTU
Animal	Not Available	Marine mussel	FooDB	DTU
Animal	Not Available	Milkfish	FooDB	34893796
Animal	Not Available	Mollusks	FooDB	34893796
Animal	Not Available	Monkfish	FooDB	34893796
Animal	Not Available	Mountain hare	FooDB	DTU
Animal	Not Available	Northern bluefin tuna	FooDB	34893796
Animal	Not Available	Northern pike	FooDB	DTU
Animal	Not Available	Norway lobster	FooDB	DTU
Animal	Not Available	Norway pout	FooDB	DTU
Animal	Not Available	Ocean pout	FooDB	34893796
Animal	Not Available	Orange roughy	FooDB	34893796
Animal	Not Available	Pacific cod	FooDB	34893796
Animal	Not Available	Pacific halibut	FooDB	34893796
Animal	Not Available	Pacific herring	FooDB	34893796
Animal	Not Available	Pacific jack mackerel	FooDB	34893796
Animal	Not Available	Pacific ocean perch	FooDB	DTU
Animal	Not Available	Pacific oyster	FooDB	34893796
Animal	Not Available	Pacific rockfish	FooDB	34893796
Animal	Not Available	Perciformes	FooDB	DTU
Animal	Not Available	Percoidei (bass and others)	FooDB	34893796
Animal	Not Available	Pig	FooDB	34893796
Animal	Not Available	Pikeperch	FooDB	DTU
Animal	Not Available	Pink salmon	FooDB	34893796
Animal	Not Available	Pleuronectidae (dab, halibut, plaice)	FooDB	DTU
Animal	Not Available	Pollock	FooDB	DTU
Animal	Not Available	Quail	FooDB	34893796
Animal	Not Available	Rainbow smelt	FooDB	34893796
Animal	Not Available	Rainbow trout	FooDB	DTU
Animal	Not Available	Red king crab	FooDB	34893796
Animal	Not Available	Sablefish	FooDB	34893796
Animal	Not Available	Salmonidae (salmon, trout)	FooDB	DTU
Animal	Not Available	Scallop	FooDB	34893796
Animal	Not Available	Scombridae (bonito, mackerel, tuna)	FooDB	DTU
Animal	Not Available	Scup	FooDB	34893796
Animal	Not Available	Sea trout	FooDB	34893796
Animal	Not Available	Shark	FooDB	34893796
Animal	Not Available	Sheefish	FooDB	34893796
Animal	Not Available	Sheepshead	FooDB	34893796
Animal	Not Available	Shrimp	FooDB	DTU
Animal	Not Available	Skipjack tuna	FooDB	34893796
Animal	Not Available	Snail	FooDB	DTU
Animal	Not Available	Snapper	FooDB	34893796
Animal	Not Available	Snow crab	FooDB	34893796
Animal	Not Available	Sockeye salmon	FooDB	34893796
Animal	Not Available	Spanish mackerel	FooDB	34893796
Animal	Not Available	Spiny dogfish	FooDB	DTU
Animal	Not Available	Spiny lobster	FooDB	34893796
Animal	Not Available	Spirulina	FooDB	34893796
Animal	Not Available	Spot croaker	FooDB	34893796
Animal	Not Available	Squab	FooDB	34893796
Animal	Not Available	Squid	FooDB	34893796
Animal	Not Available	Striped bass	FooDB	34893796
Animal	Not Available	Striped mullet	FooDB	34893796
Animal	Not Available	Sturgeon	FooDB	DTU
Animal	Not Available	Swordfish	FooDB	34893796
Animal	Not Available	Thunnus	FooDB	DTU
Animal	Not Available	Tilefish	FooDB	34893796
Animal	Not Available	True sole	FooDB	34893796
Animal	Not Available	Turbot	FooDB	DTU
Animal	Not Available	Wakame	FooDB	34893796
Animal	Not Available	Whelk	FooDB	34893796
Animal	Not Available	White sucker	FooDB	34893796
Animal	Not Available	Whitefish	FooDB	DTU
Animal	Not Available	Whiting	FooDB	DTU
Animal	Not Available	Yellowfin tuna	FooDB	34893796
Animal	Not Available	Yellowtail amberjack	FooDB	34893796
Plant	Not Available	Agave	FooDB	34893796
Plant	Not Available	Alcoholic beverage	FooDB	Manually Annotated
Plant	Not Available	Allium	FooDB	DTU
Plant	Not Available	Almond	FooDB	DTU
Plant	Not Available	Amaranth	FooDB	34893796
Plant	Not Available	Arabica coffee	FooDB	DTU
Plant	Not Available	Arrowhead	FooDB	34893796
Plant	Not Available	Arrowroot	FooDB	34893796
Plant	Not Available	Banana	FooDB	34893796
Plant	Not Available	Beer	FooDB	DTU
Plant	Not Available	Black salsify	FooDB	DTU
Plant	Not Available	Black walnut	FooDB	DTU
Plant	Not Available	Borage	FooDB	34893796
Plant	Not Available	Brandy	FooDB	DTU
Plant	Not Available	Broccoli	FooDB	DTU
Plant	Not Available	Brussel sprouts	FooDB	DTU
Plant	Not Available	Cabbage	FooDB	34893796
Plant	Not Available	Cardoon	FooDB	34893796
Plant	Not Available	Cassava	FooDB	DTU
Plant	Not Available	Cauliflower	FooDB	DTU
Plant	Not Available	Celeriac	FooDB	34893796
Plant	Not Available	Celery stalks	FooDB	34893796
Plant	Not Available	Chanterelle	FooDB	DTU
Plant	Not Available	Cherimoya	FooDB	DTU
Plant	Not Available	Chervil	FooDB	DTU
Plant	Not Available	Chicory	FooDB	DTU
Plant	Not Available	Chinese broccoli	FooDB	34893796
Plant	Not Available	Chinese cabbage	FooDB	DTU
Plant	Not Available	Chinese chives	FooDB	34893796
Plant	Not Available	Chives	FooDB	DTU
Plant	Not Available	Cinnamon	FooDB	DTU
Plant	Not Available	Cloud ear fungus	FooDB	34893796
Plant	Not Available	Common cabbage	FooDB	DTU
Plant	Not Available	Common mushroom	FooDB	DTU
Plant	Not Available	Common oregano	FooDB	34893796
Plant	Not Available	Common pea	FooDB	DTU
Plant	Not Available	Common salsify	FooDB	34893796
Plant	Not Available	Common thyme	FooDB	34893796
Plant	Not Available	Dandelion	FooDB	34893796
Plant	Not Available	Dill	FooDB	DTU
Plant	Not Available	Dock	FooDB	34893796
Plant	Not Available	Endive	FooDB	DTU
Plant	Not Available	Epazote	FooDB	34893796
Plant	Not Available	Feijoa	FooDB	34893796
Plant	Not Available	French plantain	FooDB	DTU
Plant	Not Available	Garden cress	FooDB	DTU
Plant	Not Available	Garden onion	FooDB	34893796
Plant	Not Available	Garden rhubarb	FooDB	DTU
Plant	Not Available	Garland chrysanthemum	FooDB	34893796
Plant	Not Available	Garlic	FooDB	DTU
Plant	Not Available	Giant butterbur	FooDB	34893796
Plant	Not Available	Globe artichoke	FooDB	DTU
Plant	Not Available	Green cabbage	FooDB	34893796
Plant	Not Available	Horseradish	FooDB	DTU
Plant	Not Available	Ice queen lettuce	FooDB	34893796
Plant	Not Available	Italian oregano	FooDB	34893796
Plant	Not Available	Jackfruit	FooDB	34893796
Plant	Not Available	Jerusalem artichoke	FooDB	DTU
Plant	Not Available	Jew's ear	FooDB	34893796
Plant	Not Available	Jicama	FooDB	34893796
Plant	Not Available	Jute	FooDB	34893796
Plant	Not Available	Kale	FooDB	DTU
Plant	Not Available	Kohlrabi	FooDB	DTU
Plant	Not Available	Lambsquarters	FooDB	34893796
Plant	Not Available	Lemon grass	FooDB	34893796
Plant	Not Available	Lentils	FooDB	DTU
Plant	Not Available	Lettuce	FooDB	DTU
Plant	Not Available	Loquat	FooDB	DTU
Plant	Not Available	Maitake	FooDB	34893796
Plant	Not Available	Mamey sapote	FooDB	34893796
Plant	Not Available	Mexican oregano	FooDB	34893796
Plant	Not Available	Morchella (morel)	FooDB	34893796
Plant	Not Available	Mountain yam	FooDB	34893796
Plant	Not Available	Mustard spinach	FooDB	34893796
Plant	Not Available	Nance	FooDB	34893796
Plant	Not Available	New zealand spinach	FooDB	34893796
Plant	Not Available	Nopal	FooDB	34893796
Plant	Not Available	Nutmeg	FooDB	DTU
Plant	Not Available	Okra	FooDB	DTU
Plant	Not Available	Oyster mushroom	FooDB	DTU
Plant	Not Available	Pak choy	FooDB	DTU
Plant	Not Available	Palm hearts	FooDB	34893796
Plant	Not Available	Papaya	FooDB	DTU
Plant	Not Available	Parsley	FooDB	DTU
Plant	Not Available	Parsnip	FooDB	DTU
Plant	Not Available	Peanut	FooDB	34893796
Plant	Not Available	Pepper (spice)	FooDB	DTU
Plant	Not Available	Peppermint	FooDB	34893796
Plant	Not Available	Potato	FooDB	DTU
Plant	Not Available	Prairie turnip	FooDB	34893796
Plant	Not Available	Purslane	FooDB	34893796
Plant	Not Available	Quinoa	FooDB	34893796
Plant	Not Available	Red wine	FooDB	DTU
Plant	Not Available	Rice	FooDB	34893796
Plant	Not Available	Robusta coffee	FooDB	DTU
Plant	Not Available	Rocket salad (ssp.)	FooDB	34893796
Plant	Not Available	Romaine lettuce	FooDB	DTU
Plant	Not Available	Rose wine	FooDB	DTU
Plant	Not Available	Rosemary	FooDB	34893796
Plant	Not Available	Round kumquat	FooDB	DTU
Plant	Not Available	Saffron	FooDB	34893796
Plant	Not Available	Sapodilla	FooDB	34893796
Plant	Not Available	Savoy cabbage	FooDB	DTU
Plant	Not Available	Shallot	FooDB	34893796
Plant	Not Available	Shiitake	FooDB	34893796
Plant	Not Available	Sorrel	FooDB	DTU
Plant	Not Available	Soy bean	FooDB	DTU
Plant	Not Available	Spearmint	FooDB	34893796
Plant	Not Available	Spinach	FooDB	DTU
Plant	Not Available	Swamp cabbage	FooDB	34893796
Plant	Not Available	Swede	FooDB	DTU
Plant	Not Available	Sweet basil	FooDB	34893796
Plant	Not Available	Sweet marjoram	FooDB	34893796
Plant	Not Available	Sweet potato	FooDB	DTU
Plant	Not Available	Swiss chard	FooDB	DTU
Plant	Not Available	Tamarind	FooDB	34893796
Plant	Not Available	Taro	FooDB	34893796
Plant	Not Available	Turnip	FooDB	DTU
Plant	Not Available	Vanilla	FooDB	34893796
Plant	Not Available	Wasabi	FooDB	34893796
Plant	Not Available	Watercress	FooDB	DTU
Plant	Not Available	Welsh onion	FooDB	34893796
Plant	Not Available	Whisky	FooDB	DTU
Plant	Not Available	White cabbage	FooDB	DTU
Plant	Not Available	White wine	FooDB	DTU
Plant	Not Available	Wild celery	FooDB	DTU
Plant	Not Available	Wild leek	FooDB	DTU
Plant	Not Available	Yardlong bean	FooDB	34893796
Plant	Not Available	Yautia	FooDB	34893796
Plant	Bean	Common bean	FooDB	DTU
Plant	Bean sprout	Common bean	FooDB	DTU
Plant	Bean sprout	Mung bean	FooDB	DTU
Animal	Brain	Cow	FooDB	34893796
Plant	Bud	Garland chrysanthemum	FooDB	DUKE
Plant	Bulb	Fennel	FooDB	34893796
Plant	Bulb and lower leaf-portion	Wild leek	FooDB	34893796
Plant	Cocoa products	Cocoa bean	FooDB	DTU
Plant	Coffee	Arabica coffee	FooDB	DTU
Plant	Coffee	Robusta coffee	FooDB	DTU
Animal	Egg	Anser	FooDB	DTU
Animal	Egg	Chicken	FooDB	DTU
Animal	Egg	Mallard duck	FooDB	DTU
Animal	Egg	Whitefish	FooDB	34893796
Animal	Fat	Anser	FooDB	DTU
Animal	Fat	Cow	FooDB	DTU
Animal	Fat	Domestic pig	FooDB	DTU
Animal	Fat	Wild boar	FooDB	DTU
Animal	Fillet	Blue whiting	FooDB	DTU
Animal	Fillet	Catfish	FooDB	DTU
Animal	Fillet	Common ling	FooDB	DTU
Animal	Fillet	Gadus (common cod)	FooDB	DTU
Animal	Fillet	Norway haddock	FooDB	DTU
Animal	Fillet	Pollock	FooDB	DTU
Animal	Fllet	Gadus (common cod)	FooDB	DTU
Plant	Flour	Arrowroot	FooDB	34893796
Plant	Flour	Carob	FooDB	34893796
Plant	Flour	Chickpea	FooDB	34893796
Plant	Flour	Peanut	FooDB	34893796
Plant	Flour	Potato	FooDB	DTU
Plant	Flour	Soy bean	FooDB	DTU
Plant	Flower	Sesbania flower	FooDB	34893796
Plant	Fruit	Acerola	FooDB	34893796
Plant	Fruit	Acorn squash	FooDB	34893796
Plant	Fruit	Alaska blueberry	FooDB	34893796
Plant	Fruit	American cranberry	FooDB	DUKE
Plant	Fruit	Apple	FooDB	DTU
Plant	Fruit	Apricot	FooDB	DTU
Plant	Fruit	Asian pear	FooDB	34893796
Plant	Fruit	Avocado	FooDB	DTU
Plant	Fruit	Bilberry	FooDB	DTU
Plant	Fruit	Bitter gourd	FooDB	34893796
Plant	Fruit	Blackcurrant	FooDB	DTU
Plant	Fruit	Breadfruit	FooDB	34893796
Plant	Fruit	Butternut squash	FooDB	34893796
Plant	Fruit	Calabash	FooDB	DUKE
Plant	Fruit	Cantaloupe melon	FooDB	34893796
Plant	Fruit	Chayote	FooDB	DTU
Plant	Fruit	Clementine	FooDB	34893796
Plant	Fruit	Coconut	FooDB	DTU
Plant	Fruit	Common chokecherry	FooDB	34893796
Plant	Fruit	Common grape	FooDB	DUKE
Plant	Fruit	Cucumber	FooDB	DTU
Plant	Fruit	Cucurbita	FooDB	DTU
Plant	Fruit	Custard apple	FooDB	34893796
Plant	Fruit	Date	FooDB	DTU
Plant	Fruit	Durian	FooDB	34893796
Plant	Fruit	Eggplant	FooDB	DTU
Plant	Fruit	Elderberry	FooDB	DTU
Plant	Fruit	European plum	FooDB	DTU
Plant	Fruit	Fig	FooDB	DTU
Plant	Fruit	Garden tomato	FooDB	DTU
Plant	Fruit	Garden tomato (var.)	FooDB	DUKE
Plant	Fruit	Gooseberry	FooDB	DTU
Plant	Fruit	Grape	FooDB	DTU
Plant	Fruit	Grapefruit	FooDB	DTU
Plant	Fruit	Grapefruit/pummelo hybrid	FooDB	34893796
Plant	Fruit	Green zucchini	FooDB	DTU
Plant	Fruit	Groundcherry	FooDB	DTU
Plant	Fruit	Guava	FooDB	DTU
Plant	Fruit	Highbush blueberry	FooDB	DUKE
Plant	Fruit	Horned melon	FooDB	34893796
Plant	Fruit	Jalapeno	FooDB	34893796
Plant	Fruit	Japanese persimmon	FooDB	34893796
Plant	Fruit	Java plum	FooDB	DUKE
Plant	Fruit	Kiwi	FooDB	DTU
Plant	Fruit	Lemon	FooDB	DTU
Plant	Fruit	Lichee	FooDB	DTU
Plant	Fruit	Lime	FooDB	DTU
Plant	Fruit	Lingonberry	FooDB	DTU
Plant	Fruit	Loganberry	FooDB	DTU
Plant	Fruit	Malus (crab apple)	FooDB	DTU
Plant	Fruit	Mandarin orange (clementine, tangerine)	FooDB	DTU
Plant	Fruit	Mango	FooDB	DTU
Plant	Fruit	Monk fruit	FooDB	34893796
Plant	Fruit	Muscadine grape	FooDB	34893796
Plant	Fruit	Muskmelon	FooDB	DTU
Plant	Fruit	Nectarine	FooDB	DTU
Plant	Fruit	Passion fruit	FooDB	DTU
Plant	Fruit	Peach	FooDB	DTU
Plant	Fruit	Peach (var.)	FooDB	34893796
Plant	Fruit	Pear	FooDB	DTU
Plant	Fruit	Pepper	FooDB	All-Creatures
Plant	Fruit	Pepper (c. frutescens)	FooDB	DUKE
Plant	Fruit	Persian lime	FooDB	34893796
Plant	Fruit	Persimmon	FooDB	DTU
Plant	Fruit	Pineapple	FooDB	DTU
Plant	Fruit	Plums	FooDB	34893796
Plant	Fruit	Pomegranate	FooDB	DTU
Plant	Fruit	Prickly pear	FooDB	DTU
Plant	Fruit	Prunus (cherry, plum)	FooDB	DTU
Plant	Fruit	Quince	FooDB	DTU
Plant	Fruit	Raisins	FooDB	34893796
Plant	Fruit	Redcurrant	FooDB	DTU
Plant	Fruit	Rose hip	FooDB	DTU
Plant	Fruit	Salmonberry	FooDB	34893796
Plant	Fruit	Saskatoon berry	FooDB	Wikipedia
Plant	Fruit	Sour cherry	FooDB	DUKE
Plant	Fruit	Soursop	FooDB	34893796
Plant	Fruit	Star fruit	FooDB	DTU
Plant	Fruit	Strawberry	FooDB	DTU
Plant	Fruit	Sunburst squash (pattypan squash)	FooDB	DTU
Plant	Fruit	Sweet orange	FooDB	DTU
Plant	Fruit	Tamarind	FooDB	DTU
Plant	Fruit	Tinda	FooDB	34893796
Plant	Fruit	Vaccinium (blueberry, cranberry, huckleberry)	FooDB	DTU
Plant	Fruit	Watermelon	FooDB	DTU
Plant	Fruit	Wax gourd	FooDB	34893796
Plant	Fruit	Winter squash	FooDB	CalorieSlism
Plant	Ground	Allspice	FooDB	34893796
Plant	Ground	Cinnamon	FooDB	34893796
Plant	Ground	Cloves	FooDB	34893796
Plant	Ground	Nutmeg	FooDB	34893796
Plant	Ground	Turmeric	FooDB	34893796
Animal	Hand	Pig	FooDB	DTU
Animal	Hand with rind	Pig	FooDB	DTU
Animal	Heart	Chicken	FooDB	DTU
Animal	Heart	Cow	FooDB	DTU
Animal	Heart	Pig	FooDB	DTU
Animal	Hind leg without rind	Pig	FooDB	DTU
Plant	Juice	American cranberry	FooDB	34893796
Plant	Juice	Blackcurrant	FooDB	DTU
Plant	Juice	Elderberry	FooDB	DTU
Plant	Juice	Grape	FooDB	DTU
Plant	Juice	Lemon	FooDB	DTU
Plant	Juice	Prunus (cherry, plum)	FooDB	DTU
Plant	Juice	Strawberry	FooDB	DTU
Animal	Kidney	Cow	FooDB	DTU
Animal	Kidney	Pig	FooDB	DTU
Plant	Leaves	Amaranth	FooDB	DUKE
Plant	Leaves	Brussel sprouts	FooDB	DUKE
Plant	Leaves	Cabbage	FooDB	DUKE
Plant	Leaves	Celery leaves	FooDB	DTU
Plant	Leaves	Coriander	FooDB	DTU
Plant	Leaves	Dandelion	FooDB	DTU
Plant	Leaves	Endive	FooDB	DUKE
Plant	Leaves	Fireweed	FooDB	34893796
Plant	Leaves	Jute	FooDB	DUKE
Plant	Leaves	Tea	FooDB	DTU
Plant	Leaves	White cabbage	FooDB	DUKE
Animal	Leg	Cow	FooDB	34893796
Animal	Leg	True frog	FooDB	DTU
Animal	Leg meat	Pig	FooDB	DTU
Animal	Leg with knuckle	Pig	FooDB	DTU
Animal	Liver	Chicken	FooDB	DTU
Animal	Liver	Cow	FooDB	DTU
Animal	Liver	Duck	FooDB	DTU
Animal	Liver	Gadus (common cod)	FooDB	DTU
Animal	Liver	Goose	FooDB	DTU
Animal	Liver	Pig	FooDB	DTU
Animal	Lung	Cow	FooDB	34893796
Animal	Meat and skin	Chicken	FooDB	DTU
Animal	Meat and skin	Duck	FooDB	DTU
Animal	Meat and skin	Goose	FooDB	DTU
Animal	Meat and skin	Pig	FooDB	DTU
Animal	Meat and skin	Squab	FooDB	34893796
Animal	Meat and skin	Turkey	FooDB	DTU
Animal	Milk	Cow	FooDB	30994344
Animal	Milk	Domestic goat	FooDB	DTU
Animal	Milk	Human	FooDB	DTU
Animal	Neck	Pig	FooDB	DTU
Plant	Nut	Acorn	FooDB	34893796
Plant	Nut	Almond	FooDB	34893796
Plant	Nut	Beech nut	FooDB	34893796
Plant	Nut	Black walnut	FooDB	34893796
Plant	Nut	Brazil nut	FooDB	DTU
Plant	Nut	Butternut	FooDB	34893796
Plant	Nut	Chestnut	FooDB	DTU
Plant	Nut	Chinese chestnut	FooDB	34893796
Plant	Nut	Coconut	FooDB	34893796
Plant	Nut	Colorado pinyon	FooDB	34893796
Plant	Nut	Common hazelnut	FooDB	34893796
Plant	Nut	Common walnut	FooDB	34893796
Plant	Nut	European chestnut	FooDB	34893796
Plant	Nut	Ginkgo nuts	FooDB	34893796
Plant	Nut	Hazelnut	FooDB	DTU
Plant	Nut	Hickory nut	FooDB	34893796
Plant	Nut	Japanese chestnut	FooDB	34893796
Plant	Nut	Macadamia nut	FooDB	34893796
Plant	Nut	Macadamia nut (m. tetraphylla)	FooDB	34893796
Plant	Nut	Peanut	FooDB	DTU
Plant	Nut	Pecan nut	FooDB	DTU
Plant	Nut	Pili nut	FooDB	34893796
Plant	Nut	Pine nut	FooDB	DTU
Plant	Nut	Pistachio	FooDB	DTU
Plant	Nut	Walnut	FooDB	34893796
Animal	Oil	Gadus (common cod)	FooDB	DTU
Animal	Oil	Haddock	FooDB	DTU
Plant	Oil	Avocado	FooDB	34893796
Plant	Oil	Canola oil	FooDB	34893796
Plant	Oil	Coconut	FooDB	DTU
Plant	Oil	Cottonseed	FooDB	DTU
Plant	Oil	Cottonseed oil	FooDB	34893796
Plant	Oil	Flaxseed	FooDB	DTU
Plant	Oil	Grapeseed oil	FooDB	34893796
Plant	Oil	Oil palm	FooDB	DTU
Plant	Oil	Olive	FooDB	DTU
Plant	Oil	Peanut	FooDB	DTU
Plant	Oil	Rape	FooDB	DTU
Plant	Oil	Safflower	FooDB	DTU
Plant	Oil	Sesame	FooDB	DTU
Plant	Oil	Soy bean	FooDB	DTU
Plant	Oil	Sunflower	FooDB	DTU
Plant	Oil	Thistle	FooDB	DTU
Plant	Oil	Ucuhuba	FooDB	34893796
Plant	Oil	Walnut	FooDB	DTU
Animal	Pancreas	Cow	FooDB	34893796
Plant	Peel	Lemon	FooDB	DTU
Plant	Plant	Fenugreek	FooDB	DUKE
Plant	Plant	Parsley	FooDB	DUKE
Plant	Plant	Spinach	FooDB	DUKE
Plant	Powder	Garlic	FooDB	DTU
Plant	Powder	Rose hip	FooDB	DTU
Plant	Pulp	Naranjilla	FooDB	34893796
Animal	Rib	Cow	FooDB	34893796
Animal	Rib	Pig	FooDB	DTU
Animal	Roe	Fish	FooDB	34893796
Animal	Roe	Gadus (common cod)	FooDB	DTU
Plant	Root	Burdock	FooDB	34893796
Plant	Root	Carrot	FooDB	DTU
Plant	Root	Chicory roots	FooDB	34893796
Plant	Root	Common beet	FooDB	34893796
Plant	Root	Daikon radish	FooDB	DTU
Plant	Root	Fennel	FooDB	DTU
Plant	Root	Ginger	FooDB	DTU
Plant	Root	Horseradish	FooDB	DTU
Plant	Root	Lotus	FooDB	34893796
Plant	Root	Parsley	FooDB	DTU
Plant	Root	Parsnip	FooDB	DUKE
Plant	Root	Radish	FooDB	DUKE
Plant	Root	Red beetroot	FooDB	DTU
Plant	Root	Sweet potato	FooDB	DUKE
Plant	Root	Wasabi	FooDB	34893796
Plant	Root	Wild carrot	FooDB	DUKE
Plant	Seed	Adzuki bean	FooDB	DTU
Plant	Seed	Alfalfa	FooDB	DTU
Plant	Seed	Almond	FooDB	DUKE
Plant	Seed	Amaranth	FooDB	34893796
Plant	Seed	Anise	FooDB	34893796
Plant	Seed	Black-eyed pea	FooDB	34893796
Plant	Seed	Breadnut tree seed	FooDB	34893796
Plant	Seed	Broad bean	FooDB	34893796
Plant	Seed	Caraway	FooDB	34893796
Plant	Seed	Cashew nut	FooDB	DUKE
Plant	Seed	Catjang pea	FooDB	34893796
Plant	Seed	Chia	FooDB	34893796
Plant	Seed	Chickpea	FooDB	DTU
Plant	Seed	Common bean	FooDB	DTU
Plant	Seed	Common hazelnut	FooDB	DUKE
Plant	Seed	Common pea	FooDB	DTU
Plant	Seed	Common walnut	FooDB	DUKE
Plant	Seed	Coriander	FooDB	DTU
Plant	Seed	Cottonseed	FooDB	DUKE
Plant	Seed	Cowpea	FooDB	34893796
Plant	Seed	Cumin	FooDB	34893796
Plant	Seed	Fennel	FooDB	DTU
Plant	Seed	Fenugreek	FooDB	34893796
Plant	Seed	Flaxseed	FooDB	DTU
Plant	Seed	Gram bean	FooDB	DUKE
Plant	Seed	Hyacinth bean	FooDB	34893796
Plant	Seed	Lentils	FooDB	DUKE
Plant	Seed	Lima bean	FooDB	34893796
Plant	Seed	Lupine	FooDB	34893796
Plant	Seed	Moth bean	FooDB	34893796
Plant	Seed	Mung bean	FooDB	DTU
Plant	Seed	Peanut	FooDB	DUKE
Plant	Seed	Peas	FooDB	34893796
Plant	Seed	Pigeon pea	FooDB	34893796
Plant	Seed	Pistachio	FooDB	DUKE
Plant	Seed	Poppy	FooDB	DTU
Plant	Seed	Sesame	FooDB	DTU
Plant	Seed	Soy bean	FooDB	DTU
Plant	Seed	Star anise	FooDB	34893796
Plant	Seed	Sunburst squash (pattypan squash)	FooDB	34893796
Plant	Seed	Sunflower	FooDB	DTU
Plant	Seed	White lupine	FooDB	34893796
Plant	Seed	Winged bean	FooDB	DUKE
Plant	Seed	Winter squash	FooDB	34893796
Plant	Seed	Yardlong bean	FooDB	DUKE
Plant	Seed	Yellow pond-lily	FooDB	34893796
Plant	Seed oil	Grape	FooDB	DTU
Plant	Shoot	Asparagus	FooDB	DTU
Plant	Shoot	Bamboo shoots	FooDB	DTU
Plant	Shoot	Celeriac	FooDB	DTU
Plant	Shoot	Narrowleaf cattail	FooDB	34893796
Animal	Shoulder	Cow	FooDB	34893796
Animal	Shoulder	Pig	FooDB	DTU
Animal	Skin	Pig	FooDB	34893796
Animal	Spleen	Cow	FooDB	34893796
Plant	Sprout	Alfalfa	FooDB	34893796
Plant	Sprout	Soy bean	FooDB	DTU
Plant	Sprout seedling	Common bean	FooDB	DUKE
Plant	Sprout seedling	Lentils	FooDB	DUKE
Plant	Sprout seedling	Mung bean	FooDB	DUKE
Animal	Suet	Cow	FooDB	34893796
Plant	Tea	German camomile	FooDB	34893796
Plant	Tea	Hibiscus tea	FooDB	34893796
Plant	Tea	Tea	FooDB	34893796
Animal	Thymus	Cow	FooDB	DTU
Animal	Thymus	Sheep (mutton, lamb)	FooDB	DTU
Animal	Tongue	Cow	FooDB	DTU
Animal	Tongue	Pig	FooDB	DTU
Animal	Tripe	Cow	FooDB	34893796
Plant	Tuber	Yam	FooDB	DTU
Animal	Meat	See All	FooDB	34893796

Source Type	Source Sub-type	Source Name	Data Source	Reference
Animal	Meat	African ostrich	FooDB	34893796
Animal	Meat	Beefalo	FooDB	34893796
Animal	Meat	Bison	FooDB	34893796
Animal	Meat	Buffalo	FooDB	34893796
Animal	Meat	Chicken	FooDB	DTU
Animal	Meat	Cow	FooDB	DTU
Animal	Meat	Crab	FooDB	DTU
Animal	Meat	Deer	FooDB	34893796
Animal	Meat	Domestic goat	FooDB	34893796
Animal	Meat	Domestic pigeon	FooDB	34893796
Animal	Meat	Duck	FooDB	DTU
Animal	Meat	Elk	FooDB	34893796
Animal	Meat	Emu	FooDB	34893796
Animal	Meat	Goose	FooDB	DTU
Animal	Meat	Helmeted guineafowl	FooDB	34893796
Animal	Meat	Pheasant	FooDB	34893796
Animal	Meat	Pig	FooDB	DTU
Animal	Meat	Quail	FooDB	34893796
Animal	Meat	Rabbit	FooDB	DTU
Animal	Meat	Rock ptarmigan	FooDB	DTU
Animal	Meat	Sheep (mutton, lamb)	FooDB	DTU
Animal	Meat	Squab	FooDB	DTU
Animal	Meat	Turkey	FooDB	DTU

Other Exposures

Source Type	Data Source	Reference
Drugs	U.S. Environmental Protection Agency	CompTox
Drugs - Antimicrobial	U.S. Environmental Protection Agency	CompTox
Cosmetics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox
Domestics	U.S. Environmental Protection Agency	CompTox
Cosmetics	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0056	0.005			uM	Adult (>18 years old)	Both	Alzheimer's disease	HMDB	11959400
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.008	0.0011			uM	Elderly (>65 years old)	Both	Alzheimer's disease	HMDB	11959400
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0203	0.0017			uM	Adult (>18 years old)	Not Specified	Alzheimer's disease	HMDB	21474939
Human Blood	Detected and Quantified	0.0097				uM	Adult (>18 years old)	Male	Dimethylglycinuria	HMDB	10102904
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0209	0.00703			uM	Adult (>18 years old)	Not Specified	fibromyalgia	HMDB	20087382
Human Blood	Detected and Quantified	0.00131				uM	Infant (0-1 year old)	Male	Hereditary folate malabsorption	HMDB	20005757
Human Blood	Detected and Quantified	0.00204				uM	Infant (0-1 year old)	Female	Hereditary folate malabsorption	HMDB	3987728
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.00612				uM	Children (1-13 years old)	Male	Hereditary folate malabsorption	HMDB	20005757
Human Blood	Detected and Quantified	0.023		0.019	0.028	uM	Adult (>18 years old)	Both	Rheumatoid arthritis	HMDB	16277678
Human Blood	Detected and Quantified	0.023		0.020	0.026	uM	Adult (>18 years old)	Both	Rheumatoid arthritis	HMDB	16277678
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0544				uM	Children (1-13 years old)	Not Specified	Normal	HMDB	20005757
Human Urine	Detected and Quantified	< 0.01				umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	15321809
Human Blood	Detected and Quantified			0.00400	0.0150	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	10102904
Human Blood	Detected and Quantified			0.00544	0.0272	uM	Infant (0-1 year old)	Not Specified	Normal	HMDB	20005757
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.006	0.0005			uM	Elderly (>65 years old)	Both	Normal	HMDB	11959400
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0078	0.0011			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	11959400
Human Blood	Detected and Quantified	0.016	0.0049			uM	Adult (>18 years old)	Both	Normal	HMDB	16871332
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.0202	0.00567			uM	Adult (>18 years old)	Female	Normal	HMDB	20087382
Human Blood	Detected and Quantified	0.021		0.017	0.025	uM	Adult (>18 years old)	Both	Normal	HMDB	16277678
Human Blood	Detected and Quantified	0.023		0.002	0.045	uM	Children (1-13 years old)	Both	Normal	HMDB	16690175
Human Blood	Detected and Quantified			0.0295	0.0340	uM	Infant (0-1 year old)	Not Specified	Normal	HMDB	3987728
Human Blood	Detected and Quantified	0.003		0.0	0.007	uM	Adult (>18 years old)	Both	Folate deficiency	HMDB	Wu AHB. Tietz clinical guide to laboratory tests. 4th ed. St. Louis: Saunders/Elsevier. 2006.
Human Blood	Detected and Quantified	0.0088				uM	Children (1 - <3 years old)	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Blood	Detected and Quantified	0.0179				uM	Adolescent (14 - <19 years old	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Blood	Detected and Quantified	0.024				uM	Infant (5 days - <1 year old)	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Blood	Detected and Quantified	0.0258				uM	Children (8 - <12 years old)	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Blood	Detected and Quantified	0.027				uM	Children (3 - <6 years old)	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Blood	Detected and Quantified	0.027				uM	Adolescent (12 - <14 years old)	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Blood	Detected and Quantified	0.0297				uM	Children (6 - <8 years old)	Both	Normal	HMDB	CALIPER Paediatric Reference Intervals
Human Urine	Detected and Quantified	0.00065		0.000092	0.0013	umol/mmol creatinine	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Urine	Detected and Quantified	0.0014		0.000013	0.0026	umol/mmol creatinine	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	0.009		0.0024	0.024	uM	Adult (>18 years old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	0.009		0.0026	0.026	uM	Adult (>18 years old)	Female	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	0.011		0.004	0.028	uM	Children (1-13 years old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Blood	Detected and Quantified	0.039		0.01	0.14	uM	Newborn (0-30 days old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cerebrospinal fluid (csf)	Detected and Quantified	0.053	0.024			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cellular cytoplasm	Detected and Quantified	0.453	0.131			uM	Adult (>18 years old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cellular cytoplasm	Detected and Quantified	0.735	0.202			uM	Newborn (0-30 days old)	Not Specified	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Cellular cytoplasm	Detected and Quantified	> 0.35				uM	Adult (>18 years old)	Both	Normal	HMDB	Merck Manual of Diagnosis and Therapy.
Human Blood	Detected and Quantified	0.02		0.011	0.036	uM	Adult (>18 years old)	Both	Normal	HMDB	Wu AHB. Tietz clinical guide to laboratory tests. 4th ed. St. Louis: Saunders/Elsevier. 2006.
Human Brain	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Erythrocyte	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Kidney	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Liver	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

HMDB0000121

DrugBank ID

DB00158

Phenol Explorer Compound ID

Not Available

FooDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

27470

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

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Showing metabocard for Folic acid (MMDBc0000032)

MOL for #<Metabolite:0x00005645c750e548>

3D MOL for #<Metabolite:0x00005645c750e548>

3D SDF for #<Metabolite:0x00005645c750e548>

3D-SDF for #<Metabolite:0x00005645c750e548>

PDB for #<Metabolite:0x00005645c750e548>

3D PDB for #<Metabolite:0x00005645c750e548>

SMILES for #<Metabolite:0x00005645c750e548>

INCHI for #<Metabolite:0x00005645c750e548>

Structure for #<Metabolite:0x00005645c750e548>

3D Structure for #<Metabolite:0x00005645c750e548>