| Description | Prevotella salivae is a Gram-negative, rod-shaped microbe that thrives in mesophilic temperatures, categorized as a Chemoheterotroph, and can be found in various body sites, including the oral cavity, gut, and skin, across different species. As an Obligate Anaerobe, P. salivae requires the absence of oxygen to survive and grow. The Gram-negative cell wall structure of P. salivae is composed of a thin peptidoglycan layer and an outer membrane containing lipopolysaccharides, which contributes to its pathogenicity. Its rod-shaped morphology allows it to adhere to and colonize surfaces, facilitating its role in the oral microbiome. As a mesophilic microbe, P. salivae grows optimally at temperatures between 20-45°C, making it well-suited to the human body's normal temperature range. Its classification as a Chemoheterotroph indicates that it obtains energy by breaking down organic compounds, which is essential for its survival in the human host. P. salivae can be found in various body sites, including the oral cavity, where it plays a role in the breakdown of complex carbohydrates and the production of short-chain fatty acids. The absence of oxygen is crucial for the growth and survival of P. salivae, as it is inhibited by the presence of oxygen, highlighting its adaptation to anaerobic environments. P. salivae has been implicated in various oral diseases, including periodontitis and dental caries, and its presence has also been linked to inflammatory bowel disease and other systemic conditions, highlighting its potential role in the broader human microbiome, and recent studies have shown that P. salivae can produce antimicrobial compounds, which may have applications in the development of new therapeutic agents. |
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