MiMeDB: Showing metabocard for 14(S)-Hydroxy Docosahexaenoic Acid (MMDBc0057164)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-11-09 19:20:35 UTC

Update Date

2025-10-07 16:09:53 UTC

Metabolite ID

MMDBc0057164

Metabolite Identification

Common Name

14(S)-Hydroxy Docosahexaenoic Acid

Description

14(S)-Hydroxy Docosahexaenoic Acid is a bioactive lipid mediator belonging to the class of hydroxy fatty acids, specifically derived from omega-3 polyunsaturated fatty acids (PUFAs). Its chemical structure features a long-chain fatty acid backbone with a hydroxyl group at the 14th carbon position, which is crucial for its biological activity. 14(S)-HDHA is involved in various biochemical pathways, particularly in the resolution of inflammation. It has been shown to be elevated in conditions such as CCI/early death compared to rapid recovery, indicating its role in inflammatory responses (PMID:38488489 ). Additionally, lipidomics studies utilizing liquid chromatography-tandem mass spectrometry (LC-MS/MS) have demonstrated that 14(S)-hydroxy docosahexaenoic acid, a significant product of the 12/15-lipoxygenase (12/15-LOX) pathway, can suppress IL-33-mediated eosinophilic inflammation in models lacking 12/15-LOX (PMID:34093589 ). This suggests its potential involvement in modulating immune responses and promoting tissue homeostasis.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(14S)-HDHA	ChEBI
(14S)-Hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoic acid	ChEBI
(4Z,7Z,10Z,12E,14S,16Z,19Z)-14-Hydroxydocosahexaenoic acid	ChEBI
14(S)-HDHA	ChEBI
14(S)-HDoHE	ChEBI
14S-HDHA	ChEBI
(14S)-Hydroxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate	Generator
(4Z,7Z,10Z,12E,14S,16Z,19Z)-14-Hydroxydocosahexaenoate	Generator

Molecular Formula

C₂₂H₃₂O₃

Average Mass

344.495

Monoisotopic Mass

344.23514489

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

Not Available

InChI Key

ZNEBXONKCYFJAF-OUKOMXQNSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as very long-chain fatty acids. These are fatty acids with an aliphatic tail that contains at least 22 carbon atoms.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Fatty Acyls

Sub Class

Fatty acids and conjugates

Direct Parent

Very long-chain fatty acids

Alternative Parents

Substituents

Very long-chain fatty acid
Hydroxy fatty acid
Unsaturated fatty acid
Secondary alcohol
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Docosanoids (LMFA04000058 )

Functional Ontology

Not Available

Physical Properties

State

Not Available

Predicted Properties

Not Available

Spectra

Not Available

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (void)	2025-10-24	226.8
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	35.8
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (eluted)	2025-10-24	830.7
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	556.4
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	1045.4
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (eluted)	2025-10-24	433.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	3294.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (void)	2025-10-24	92.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	623.9
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	872.4
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	498.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	330.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	201.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	9.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	359.5
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	588.7
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	527.5
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	1777.7
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	2180.1

Retention Indices

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

52921998

PDB ID

Not Available

ChEBI ID

137347

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for 14(S)-Hydroxy Docosahexaenoic Acid (MMDBc0057164)

MOL for #<Metabolite:0x00007f9ac078e468>

3D MOL for #<Metabolite:0x00007f9ac078e468>

3D SDF for #<Metabolite:0x00007f9ac078e468>

3D-SDF for #<Metabolite:0x00007f9ac078e468>

PDB for #<Metabolite:0x00007f9ac078e468>

3D PDB for #<Metabolite:0x00007f9ac078e468>

SMILES for #<Metabolite:0x00007f9ac078e468>

INCHI for #<Metabolite:0x00007f9ac078e468>

Structure for #<Metabolite:0x00007f9ac078e468>

3D Structure for #<Metabolite:0x00007f9ac078e468>