MiMeDB: Showing metabocard for (S)-2-hydroxypropylphosphonic acid (MMDBc0055060)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2022-06-17 19:40:58 UTC

Update Date

2025-10-07 16:08:54 UTC

Metabolite ID

MMDBc0055060

Metabolite Identification

Common Name

(S)-2-hydroxypropylphosphonic acid

Description

(S)-2-hydroxypropylphosphonic acid is a phosphonic acid derivative involved in the biosynthesis of the antibiotic fosfomycin. This compound serves as a substrate for the enzyme (S)-2-hydroxypropylphosphonic acid epoxidase (HppE), a mononuclear iron enzyme that catalyzes the oxidative epoxidation of (S)-2-HPP, converting it into fosfomycin through a regio- and enantiomerically specific reaction. HppE utilizes dioxygen in its catalytic mechanism, highlighting its role in antibiotic biosynthesis pathways (PMID:24512048 , PMID:23672451 ). The enzyme's unique features, such as its non-heme iron center, contribute to its ability to facilitate this transformation (PMID:21682308 ). Studies have explored the substrate binding mode and the catalytic mechanism of HppE, providing insights into the enzymatic processes involved in fosfomycin production (PMID:17927218 , PMID:23150463 ). The conversion of structural analogues of (S)-2-hydroxypropylphosphonic acid by HppE further illustrates the enzyme's specificity and function in the antibiotic biosynthetic pathway (PMID:18155909 ). Overall, (S)-2-hydroxypropylphosphonic acid plays a crucial role as a precursor in the synthesis of a clinically significant antibiotic.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(S)-2-Hydroxypropylphosphonic acid	Generator

Molecular Formula

C₃H₈O₄P

Average Mass

139.067

Monoisotopic Mass

139.016569316

IUPAC Name

hydrogen [(2S)-2-hydroxypropyl]phosphonate

Traditional Name

(S)-2-hydroxypropylphosphonate

CAS Registry Number

Not Available

SMILES

[H][C@@](C)(O)CP(O)([O-])=O

InChI Identifier

InChI=1S/C3H9O4P/c1-3(4)2-8(5,6)7/h3-4H,2H2,1H3,(H2,5,6,7)/p-1/t3-/m0/s1

InChI Key

ZFVCONUOLQASEW-VKHMYHEASA-M

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as organic phosphonic acids. These are organic compounds containing phosphonic acid.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Organic phosphonic acids and derivatives

Sub Class

Organic phosphonic acids

Direct Parent

Organic phosphonic acids

Alternative Parents

Substituents

Organophosphonic acid
Secondary alcohol
Organic oxygen compound
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Organophosphorus compound
Organooxygen compound
Alcohol
Organic anion
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

organophosphate oxoanion (CHEBI:62246 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
logP	-1.5	ChemAxon
pKa (Strongest Acidic)	1.77	ChemAxon
pKa (Strongest Basic)	-2.6	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	80.59 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	26.89 m³·mol⁻¹	ChemAxon
Polarizability	11.19 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Deposition Date	View
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	2022-08-23	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	448.7
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	339.3
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-24	90.8
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	228.9
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (eluted)	2025-10-24	275.5
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-24	342.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (void)	2025-10-24	626.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	447.6
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	721.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	199.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	390.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	213.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	55.0
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	312.3
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	581.4
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	53.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (void)	2025-10-24	269.3
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	713.1
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	599.5

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	(S)-2-hydroxypropylphosphonic acid_TMS_1	C[C@@H](CP(=O)([O-])O)O[Si](C)(C)C	standard non polar	2025-10-24	1940.82
Gas Chromatography	(S)-2-hydroxypropylphosphonic acid_TMS_2	C[C@H](O)CP(=O)([O-])O[Si](C)(C)C	standard non polar	2025-10-24	2008.51
Gas Chromatography	(S)-2-hydroxypropylphosphonic acid_TMS_3	C[C@@H](CP(=O)([O-])O[Si](C)(C)C)O[Si](C)(C)C	standard non polar	2025-10-24	2153.32
Gas Chromatography	(S)-2-hydroxypropylphosphonic acid_TMS_1	C[C@@H](CP(=O)([O-])O)O[Si](C)(C)C	standard polar	2025-10-24	1981.83
Gas Chromatography	(S)-2-hydroxypropylphosphonic acid_TMS_2	C[C@H](O)CP(=O)([O-])O[Si](C)(C)C	standard polar	2025-10-24	1782.19
Gas Chromatography	(S)-2-hydroxypropylphosphonic acid_TMS_3	C[C@@H](CP(=O)([O-])O[Si](C)(C)C)O[Si](C)(C)C	standard polar	2025-10-24	2236.91

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	1
Bacteria	Actinobacteria	1

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

26332596

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

25244355

PDB ID

Not Available

ChEBI ID

62246

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for (S)-2-hydroxypropylphosphonic acid (MMDBc0055060)

MOL for #<Metabolite:0x00007f2e51609b28>

3D MOL for #<Metabolite:0x00007f2e51609b28>

3D SDF for #<Metabolite:0x00007f2e51609b28>

3D-SDF for #<Metabolite:0x00007f2e51609b28>

PDB for #<Metabolite:0x00007f2e51609b28>

3D PDB for #<Metabolite:0x00007f2e51609b28>

SMILES for #<Metabolite:0x00007f2e51609b28>

INCHI for #<Metabolite:0x00007f2e51609b28>

Structure for #<Metabolite:0x00007f2e51609b28>

3D Structure for #<Metabolite:0x00007f2e51609b28>