MiMeDB: Showing metabocard for 10-Formyltetrahydrofolate-[Glu](5) (MMDBc0049787)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2022-04-29 22:42:36 UTC

Update Date

2022-09-01 02:16:32 UTC

Metabolite ID

MMDBc0049787

Metabolite Identification

Common Name

10-Formyltetrahydrofolate-[Glu](5)

Description

Based on a literature review very few articles have been published on (2R,3R)-N-[(5S)-5-({[(2R)-2-amino-3-selanylpropanoyl]asparagyllysylasparagyl}amino)-6-asparagyltryptophyl-6-oxohexyl]-3-methyl-3,4-dihydro-2H-pyrrole-2-carboxamide.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₄₀H₄₅N₁₁O₁₉

Average Mass

983.861

Monoisotopic Mass

983.292609752

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

Not Available

SMILES

Not Available

InChI Identifier

InChI=1S/C40H51N11O19/c41-40-49-32-31(37(66)50-40)43-19(15-42-32)16-51(17-52)20-3-1-18(2-4-20)33(62)47-24(38(67)68)5-10-26(53)44-21(6-11-27(54)55)34(63)45-22(7-12-28(56)57)35(64)46-23(8-13-29(58)59)36(65)48-25(39(69)70)9-14-30(60)61/h1-4,17,19,21-25,43H,5-16H2,(H,44,53)(H,45,63)(H,46,64)(H,47,62)(H,48,65)(H,54,55)(H,56,57)(H,58,59)(H,60,61)(H,67,68)(H,69,70)(H4,41,42,49,50,66)/p-6

InChI Key

RGSLBOWMZCMTRA-UHFFFAOYSA-H

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Feces

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Data Source	Reference
MMDBr0001233	10-Formyltetrahydrofolic acid	10-Formyltetrahydrofolate-[Glu](5)	folylpolyglutamate synthase	VMH	10777604
MMDBr0001234	10-Formyltetrahydrofolate-[Glu](5)	10-Formyltetrahydrofolate-[Glu](6)	folylpolyglutamate synthase	VMH	10777604
MMDBr0001235	10-Formyltetrahydrofolate-[Glu](5)	10-Formyltetrahydrofolate-[Glu](6)	folylpolyglutamate synthase	VMH	10777604
MMDBr0001282	10-Formyltetrahydrofolate-[Glu](5)	10-Formyltetrahydrofolic acid	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	VMH	11375437 2867095 9614206
MMDBr0001283	10-Formyltetrahydrofolate-[Glu](5)	10-Formyltetrahydrofolic acid	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	VMH	11375437 2867095 9614206
MMDBr0001284	10-Formyltetrahydrofolate-[Glu](6)	10-Formyltetrahydrofolate-[Glu](5)	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	VMH	11375437 2867095 9614206
MMDBr0001285	10-Formyltetrahydrofolate-[Glu](6)	10-Formyltetrahydrofolate-[Glu](5)	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	VMH	11375437 2867095 9614206
MMDBr0007405	10-Formyltetrahydrofolic acid	10-Formyltetrahydrofolate-[Glu](5)	Not Available	VMH	30371894

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Proteobacteria	170	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal	Metabolic reconstruction
Bacteria/Eubacteria	Firmicutes	354	Pig ; Human feces; Human ; Human supragingival plaque; Human saliva; Cattle ; Human stool; Human subgingival plaque	Metabolic reconstruction
Bacteria	Actinobacteria	15	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva	Metabolic reconstruction
Bacteria/Eubacteria	Actinobacteria	112	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva	Metabolic reconstruction
Bacteria/Eubacteria	Verrucomicrobia	1	Human ; Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Bacteroidetes	129	Human feces; Human appendix biopsy; Human ; Human stool; Human urine; Human gastric fluid; Human saliva; Human subgingival plaque; Human supragingival plaque	Metabolic reconstruction
Bacteria	Proteobacteria	7	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal	Metabolic reconstruction
Bacteria/Eubacteria	Spirochaetes	1	Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Fusobacteria	20	Human feces; Human	Metabolic reconstruction
Bacteria/Eubacteria	Synergistetes	2	Human feces	Metabolic reconstruction
Bacteria	Firmicutes	27	Pig ; Human feces; Human ; Human supragingival plaque; Human saliva; Cattle ; Human stool; Human subgingival plaque	Metabolic reconstruction
Archaea	Euryarchaeota	2		Metabolic reconstruction
Eukaryota/Fungi	Ascomycota	1		Metabolic reconstruction
Bacteria/Eubacteria	Planctomycetes	1	Human feces	Metabolic reconstruction

Exposure Sources

Source Type	Activity	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

McGuire JJ, Russell CA, Balinska M: Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines. J Biol Chem. 2000 Apr 28;275(17):13012-6. doi: 10.1074/jbc.275.17.13012. [PubMed:10777604 ]
Suh JR, Herbig AK, Stover PJ: New perspectives on folate catabolism. Annu Rev Nutr. 2001;21:255-82. doi: 10.1146/annurev.nutr.21.1.255. [PubMed:11375437 ]
Noronha A, Modamio J, Jarosz Y, Guerard E, Sompairac N, Preciat G, Danielsdottir AD, Krecke M, Merten D, Haraldsdottir HS, Heinken A, Heirendt L, Magnusdottir S, Ravcheev DA, Sahoo S, Gawron P, Friscioni L, Garcia B, Prendergast M, Puente A, Rodrigues M, Roy A, Rouquaya M, Wiltgen L, Zagare A, John E, Krueger M, Kuperstein I, Zinovyev A, Schneider R, Fleming RMT, Thiele I: The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992. [PubMed:30371894 ]

Showing metabocard for 10-Formyltetrahydrofolate-[Glu](5) (MMDBc0049787)

MOL for #<Metabolite:0x0000564a5fb257f0>

3D MOL for #<Metabolite:0x0000564a5fb257f0>

3D SDF for #<Metabolite:0x0000564a5fb257f0>

3D-SDF for #<Metabolite:0x0000564a5fb257f0>

PDB for #<Metabolite:0x0000564a5fb257f0>

3D PDB for #<Metabolite:0x0000564a5fb257f0>

SMILES for #<Metabolite:0x0000564a5fb257f0>

INCHI for #<Metabolite:0x0000564a5fb257f0>

Structure for #<Metabolite:0x0000564a5fb257f0>

3D Structure for #<Metabolite:0x0000564a5fb257f0>