MiMeDB: Showing metabocard for Glyceraldehyde 3-phosphate (MMDBc0047921)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2021-11-23 23:15:20 UTC

Update Date

2024-10-15 17:41:58 UTC

Metabolite ID

MMDBc0047921

Metabolite Identification

Common Name

Glyceraldehyde 3-phosphate

Description

Glyceraldehyde 3-phosphate (G3P) (CAS: 591-59-3), also known as triose phosphate, belongs to the class of organic compounds known as glyceraldehyde-3-phosphates. Glyceraldehyde-3-phosphates are compounds containing a glyceraldehyde substituted at position O3 by a phosphate group. Glyceraldehyde 3-phosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Glyceraldehyde 3-phosphate has been detected, but not quantified in, several different foods, such as sea-buckthorn berries, lingonberries, prunus (cherry, plum), quinoa, and sparkleberries. This could make glyceraldehyde 3-phosphate a potential biomarker for the consumption of these foods. Glyceraldehyde 3-phosphate is an aldotriose, an important metabolic intermediate in both glycolysis and gluconeogenesis, and in tryptophan biosynthesis. G3P is formed from fructose 1,6-bisphosphate, dihydroxyacetone phosphate (DHAP), and 1,3-bisphosphoglycerate (1,3BPG). This is the process by which glycerol (as DHAP) enters the glycolytic and gluconeogenesis pathways.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Not Available

Molecular Formula

C₃H₇O₆P

Average Mass

170.0578

Monoisotopic Mass

169.998024468

IUPAC Name

Not Available

Traditional Name

Not Available

CAS Registry Number

591-57-1

SMILES

Not Available

InChI Identifier

InChI=1S/C3H7O6P/c4-1-3(5)2-9-10(6,7)8/h1,3,5H,2H2,(H2,6,7,8)/t3-/m0/s1

InChI Key

LXJXRIRHZLFYRP-VKHMYHEASA-N

Chemical Taxonomy

Functional Ontology

Not Available

Physical Properties

State

Solid

Predicted Properties

Not Available

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Blood
Cellular Cytoplasm
Feces
Fibroblasts
Kidney
Skeletal Muscle
Urine

Tissue Locations

Fibroblasts
Kidney
Skeletal Muscle

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species
MMDBp0192328	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	Unknown	O14556	Homo sapiens
MMDBp0192334	Glyceraldehyde-3-phosphate dehydrogenase	Unknown	P04406	Homo sapiens
MMDBp0192420	Transketolase-like protein 1	Unknown	P51854	Homo sapiens
MMDBp0192422	Transaldolase	Enzyme	P37837	Homo sapiens
MMDBp0192425	Transketolase	Unknown	P29401	Homo sapiens
MMDBp0192563	Putative deoxyribose-phosphate aldolase	Enzyme	Q9Y315	Homo sapiens
MMDBp0192590	Fructose-bisphosphate aldolase A	Enzyme	P04075	Homo sapiens
MMDBp0192591	Fructose-bisphosphate aldolase C	Enzyme	P09972	Homo sapiens
MMDBp0192592	Fructose-bisphosphate aldolase B	Enzyme	P05062	Homo sapiens
MMDBp0193138	Triosephosphate isomerase	Enzyme	P60174	Homo sapiens
MMDBp0193578	Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)	Enzyme	Q3LXA3	Homo sapiens
MMDBp0194009	Solute carrier organic anion transporter family member 2A1	Transporter	Q92959	Homo sapiens
MMDBp0194056	Transketolase-like protein 2	Unknown	Q9H0I9	Homo sapiens
MMDBp0196145	Triosephosphate isomerase	Enzyme	Q2QD09	Homo sapiens
MMDBp0196244	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	Q2TSD0	Homo sapiens

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Data Source	Reference
MMDBr0000828	Deoxyribose 5-phosphate	Acetaldehyde	Not Available	VMH; KEGG	30371894
MMDBr0001653	Glyceraldehyde 3-phosphate	BPG	Not Available	VMH	1537826 16037240 8853285
MMDBr0002275	D-Glyceraldehyde	Glyceraldehyde 3-phosphate	Not Available	VMH; KEGG	30371894
MMDBr0007156	Xylulose 5-phosphate	Acetyl phosphate	Not Available	VMH	30371894
MMDBr0007326	Glyceraldehyde 3-phosphate	1-Deoxy-D-xylulose 5-phosphate	Not Available	VMH	30371894
MMDBr0007396	Fructose 1,6-bisphosphate	Dihydroxyacetone phosphate	Not Available	VMH; KEGG	30371894
MMDBr0007423	Glyceraldehyde 3-phosphate	Glyceric acid 1,3-biphosphate	Not Available	VMH; KEGG	30371894
MMDBr0007529	Glyceraldehyde 3-phosphate	L-Glutamic acid	Not Available	VMH	30371894
MMDBr0007574	Glyceraldehyde 3-phosphate	D-Erythrose 4-phosphate	Not Available	VMH; KEGG	30371894
MMDBr0007578	D-Ribose-5-phosphate	Glyceraldehyde 3-phosphate	Not Available	VMH	30371894
MMDBr0007579	D-Erythrose 4-phosphate	Fructose 6-phosphate	Not Available	VMH; KEGG	30371894
MMDBr0007584	Dihydroxyacetone phosphate	Glyceraldehyde 3-phosphate	Not Available	VMH; KEGG	30371894
MMDBr0007756	Deoxyribose 5-phosphate	Acetaldehyde	Not Available	VMH	30371894
MMDBr0008147	2-Dehydro-3-deoxy-D-galactonate 6-phosphate	Glyceraldehyde 3-phosphate	Not Available	VMH	30371894
MMDBr0008325	Glyceraldehyde 3-phosphate	Glyceric acid 1,3-biphosphate	Not Available	VMH	30371894
MMDBr0008471	Xylulose 5-phosphate	Acetyl phosphate	Not Available	VMH	30371894
MMDBr0008531	Glyceraldehyde 3-phosphate	3-Phospho-D-glycerate	Not Available	VMH	30371894

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Firmicutes	363	Human feces; Human pleural fluid plaque; Pig ; Human sputum; Human ; Human subgingival plaque; Human saliva; Human urine; Human mucosa; Human supragingival plaque; Cattle ; Human stool	Metabolic reconstruction
Bacteria/Eubacteria	Proteobacteria	174	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal	Metabolic reconstruction
Bacteria	Actinobacteria	15	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva	Metabolic reconstruction
Bacteria/Eubacteria	Actinobacteria	113	Human feces; Human sputum; Human bronchial brush; Human nasopharyngeal swab; Human pleural fluid plaque; Human dental plaque; Human ; Human supragingival plaque; Human mucosa; Human subgingival plaque; Human saliva	Metabolic reconstruction
Bacteria/Eubacteria	Verrucomicrobia	1	Human ; Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Bacteroidetes	126	Human feces; Human appendix biopsy; Human ; Human stool; Human saliva; Human gastric fluid; Human subgingival plaque; Human urine; Human supragingival plaque	Metabolic reconstruction
Bacteria/Eubacteria	Synergistetes	3	Human feces	Metabolic reconstruction
Bacteria	Firmicutes	28	Human feces; Human pleural fluid plaque; Pig ; Human sputum; Human ; Human subgingival plaque; Human saliva; Human urine; Human mucosa; Human supragingival plaque; Cattle ; Human stool	Metabolic reconstruction
Bacteria	Proteobacteria	7	Human feces; Human sputum; Human ; Human unknown; Pig ; Human pleural fluid plaque; Human dental plaque; Human nasal swab; Human stool; Human feces; pleural fluid plaque; bal	Metabolic reconstruction
Bacteria/Eubacteria	Spirochaetes	1	Human feces	Metabolic reconstruction
Archaea	Thaumarchaeota	1		Metabolic reconstruction
Bacteria/Eubacteria	Fusobacteria	20	Human feces; Human	Metabolic reconstruction
Archaea	Euryarchaeota	5		Metabolic reconstruction
Bacteria	Candidatus melainabacteria	1	Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Tenericutes	4	Human feces	Metabolic reconstruction
Bacteria/Eubacteria	Planctomycetes	1	Human feces	Metabolic reconstruction
Archaea	Crenarchaeota	1		Metabolic reconstruction
Bacteria	Synergistetes	1	Human feces	Metabolic reconstruction

Exposure Sources

Source Type	Activity	Data Source	Reference
Drugs	Antimicrobial	U.S. Environmental Protection Agency	CompTox
Cosmetics	Not Available	U.S. Environmental Protection Agency	CompTox
Domestics	Not Available	U.S. Environmental Protection Agency	CompTox

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Feces	Detected but not Quantified									HMDB
Human Cellular cytoplasm	Detected and Quantified	6.70		5.70	7.70	uM	Adult (>18 years old)	Both	Normal	HMDB	15882454
Human Blood	Detected and Quantified	4.8	1.6			uM	Adult (>18 years old)	Both	Normal	HMDB	Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
Human Fibroblasts	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Kidney	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Skeletal muscle	Detected but not Quantified						Not Specified	Not Specified	Normal	HMDB	34986597
Human Urine	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057
Human Blood	Detected but not Quantified						Adult (>18 years old)	Both	Normal	HMDB	32966057

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

Not Available

PDB ID

Not Available

ChEBI ID

Not Available

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Yamamoto T, Moriwaki Y, Takahashi S, Ohata H, Nakano T, Yamakita J, Higashino K: Effect of glucagon on the xylitol-induced increase in the plasma concentration and urinary excretion of purine bases. Metabolism. 1996 Nov;45(11):1354-9. doi: 10.1016/s0026-0495(96)90115-8. [PubMed:8931639 ]
Modun B, Morrissey J, Williams P: The staphylococcal transferrin receptor: a glycolytic enzyme with novel functions. Trends Microbiol. 2000 May;8(5):231-7. doi: 10.1016/s0966-842x(00)01728-5. [PubMed:10785640 ]
Zhang J, Jung K, Lein M, Kristiansen G, Rudolph B, Hauptmann S, Schnorr D, Loening SA, Lichtinghagen R: Differential expression of matrix metalloproteinases and their tissue inhibitors in human primary cultured prostatic cells and malignant prostate cell lines. Prostate. 2002 Jan 1;50(1):38-45. doi: 10.1002/pros.10030. [PubMed:11757034 ]
Harper LV, Hilton AC, Jones AF: RT-PCR for the pseudogene-free amplification of the glyceraldehyde-3-phosphate dehydrogenase gene (gapd). Mol Cell Probes. 2003 Oct;17(5):261-5. doi: 10.1016/s0890-8508(03)00063-x. [PubMed:14580401 ]
Choei H, Sasaki N, Takeuchi M, Yoshida T, Ukai W, Yamagishi S, Kikuchi S, Saito T: Glyceraldehyde-derived advanced glycation end products in Alzheimer's disease. Acta Neuropathol. 2004 Sep;108(3):189-93. doi: 10.1007/s00401-004-0871-x. Epub 2004 Jun 17. [PubMed:15221334 ]
Nakayama Y, Kinoshita A, Tomita M: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition. Theor Biol Med Model. 2005 May 9;2:18. doi: 10.1186/1742-4682-2-18. [PubMed:15882454 ]
Yang Y, Hou Y, Wang CL, Ji SJ: Renal expression of epidermal growth factor and transforming growth factor-beta1 in children with congenital hydronephrosis. Urology. 2006 Apr;67(4):817-21; discussion 821-2. doi: 10.1016/j.urology.2005.10.062. [PubMed:16618565 ]
Kogler H, Schott P, Toischer K, Milting H, Van PN, Kohlhaas M, Grebe C, Kassner A, Domeier E, Teucher N, Seidler T, Knoll R, Maier LS, El-Banayosy A, Korfer R, Hasenfuss G: Relevance of brain natriuretic peptide in preload-dependent regulation of cardiac sarcoplasmic reticulum Ca2+ ATPase expression. Circulation. 2006 Jun 13;113(23):2724-32. doi: 10.1161/CIRCULATIONAHA.105.608828. Epub 2006 Jun 5. [PubMed:16754798 ]

Showing metabocard for Glyceraldehyde 3-phosphate (MMDBc0047921)

MOL for #<Metabolite:0x00007f3e34f04410>

3D MOL for #<Metabolite:0x00007f3e34f04410>

3D SDF for #<Metabolite:0x00007f3e34f04410>

3D-SDF for #<Metabolite:0x00007f3e34f04410>

PDB for #<Metabolite:0x00007f3e34f04410>

3D PDB for #<Metabolite:0x00007f3e34f04410>

SMILES for #<Metabolite:0x00007f3e34f04410>

INCHI for #<Metabolite:0x00007f3e34f04410>

Structure for #<Metabolite:0x00007f3e34f04410>

3D Structure for #<Metabolite:0x00007f3e34f04410>