MiMeDB: Showing metabocard for dehydro-D-arabinono-1,4-lactone (MMDBc0032944)

Record Information

Version

2.0

Status

Detected and Quantified

Creation Date

2021-11-19 04:28:20 UTC

Update Date

2025-10-07 16:07:52 UTC

Metabolite ID

MMDBc0032944

Metabolite Identification

Common Name

dehydro-D-arabinono-1,4-lactone

Description

dehydro-D-arabinono-1,4-lactone is a lactone, a chemical class characterized by a cyclic ester formed from the condensation of a hydroxy acid. There is little literature available on this metabolite, indicating that further research may be needed to fully understand its biological significance and potential applications.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(5R)-3,4-Dihydroxy-5-(hydroxymethyl)furan-2(5H)-one	ChEBI
D-Erythroascorbic acid	ChEBI
D-Glycero-2-pentenono-L,4-lactone	ChEBI
D-Erythroascorbate	Generator
D-erythro-Ascorbic acid	ChEBI
D-erythro-Ascorbate	Generator

Molecular Formula

C₅H₆O₅

Average Mass

146.0981

Monoisotopic Mass

146.021523302

IUPAC Name

(5R)-3,4-dihydroxy-5-(hydroxymethyl)-2,5-dihydrofuran-2-one

Traditional Name

(5R)-3,4-dihydroxy-5-(hydroxymethyl)-5H-furan-2-one

CAS Registry Number

Not Available

SMILES

OC[C@H]1OC(=O)C(O)=C1O

InChI Identifier

InChI=1S/C5H6O5/c6-1-2-3(7)4(8)5(9)10-2/h2,6-8H,1H2/t2-/m1/s1

InChI Key

ZZZCUOFIHGPKAK-UWTATZPHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Dihydrofurans

Sub Class

Furanones

Direct Parent

Butenolides

Alternative Parents

Substituents

2-furanone
Monosaccharide
Enoate ester
Alpha,beta-unsaturated carboxylic ester
Vinylogous acid
Lactone
Enediol
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Oxacycle
Alcohol
Primary alcohol
Organooxygen compound
Organic oxide
Carbonyl group
Organic oxygen compound
Hydrocarbon derivative
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

gamma-lactone (CHEBI:17803 )

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	492 g/L	ALOGPS
logP	-1.5	ALOGPS
logP	-1.3	ChemAxon
logS	0.53	ALOGPS
pKa (Strongest Acidic)	4.43	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	86.99 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	31.07 m³·mol⁻¹	ChemAxon
Polarizability	12.16 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0fml-9400000000-0d77717d2b9ce05e1490	2016-09-22	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0092-4900000000-9ee98b4343f1aa95af8b	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-004j-3900000000-d46dd03e3548f69a2e6f	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-006x-9100000000-f44e59e90024a0f46dd8	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-2900000000-f79f94d04fbe8375b1a2	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-002b-2900000000-74bc961b219187ae72c4	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9200000000-a22b22eac355e6c2bab4	2016-09-12	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-23	View Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)		2022-08-23	View Spectrum

Chromatographic Retention Times and Retention Indices

Retention Times

Chromatography Type	Technique	Column	Deposition Date	Retention Time (s)
Liquid Chromatography	HILIC	Waters Acquity UPLC-BEH Amide column (eluted)	2025-10-24	212.1
Liquid Chromatography	HILIC	Accucore 150 Amide HILIC (eluted)	2025-10-24	114.3
Liquid Chromatography	Reversed-phase	Hypersil Gold 1.9 µm C18 (void)	2025-10-24	153.6
Liquid Chromatography	Reversed-phase	Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) (eluted)	2025-10-24	350.8
Liquid Chromatography	Reversed-phase	XBridge C18 3.5u 2.1x50 mm (void)	2025-10-24	465.9
Liquid Chromatography	Reversed-phase	Ascentis Express C18 (void)	2025-10-24	422.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	1478.8
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	554.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC (eluted)	2025-10-24	1113.8
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	289.5
Liquid Chromatography	HILIC	Merck SeQuant ZIC-HILIC (eluted)	2025-10-24	299.0
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC HSS T3 C18 (eluted)	2025-10-24	278.1
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	86.9
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	388.2
Liquid Chromatography	HILIC	Merck SeQuant ZIC-pHILIC column (eluted)	2025-10-24	876.3
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	99.2
Liquid Chromatography	Reversed-phase	Waters ACQUITY UPLC BEH C18 (eluted)	2025-10-24	402.9
Liquid Chromatography	Reversed-phase	Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex (eluted)	2025-10-24	1297.8
Liquid Chromatography	Reversed-phase	Waters Atlantis T3 (2.1 x 150 mm, 5 um) (eluted)	2025-10-24	806.2

Retention Indices

Chromatography Type	Peak Label	SMILES	Stationary Phase	Deposition Date	Retention Index
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_1	C[Si](C)(C)OC[C@H]1OC(=O)C(O)=C1O	standard non polar	2025-10-24	1989.11
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_2	C[Si](C)(C)OC1=C(O)[C@@H](CO)OC1=O	standard non polar	2025-10-24	2239.97
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_3	C[Si](C)(C)OC1=C(O)C(=O)O[C@@H]1CO	standard non polar	2025-10-24	1936.76
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_4	C[Si](C)(C)OC[C@H]1OC(=O)C(O[Si](C)(C)C)=C1O	standard non polar	2025-10-24	2232.92
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_5	C[Si](C)(C)OC[C@H]1OC(=O)C(O)=C1O[Si](C)(C)C	standard non polar	2025-10-24	1589.31
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_6	C[Si](C)(C)OC1=C(O[Si](C)(C)C)[C@@H](CO)OC1=O	standard non polar	2025-10-24	2104.5
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_7	C[Si](C)(C)OC[C@H]1OC(=O)C(O[Si](C)(C)C)=C1O[Si](C)(C)C	standard non polar	2025-10-24	2265.41
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_1	C[Si](C)(C)OC[C@H]1OC(=O)C(O)=C1O	standard polar	2025-10-24	2362.0
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_2	C[Si](C)(C)OC1=C(O)[C@@H](CO)OC1=O	standard polar	2025-10-24	1849.87
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_3	C[Si](C)(C)OC1=C(O)C(=O)O[C@@H]1CO	standard polar	2025-10-24	2168.35
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_4	C[Si](C)(C)OC[C@H]1OC(=O)C(O[Si](C)(C)C)=C1O	standard polar	2025-10-24	2330.42
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_5	C[Si](C)(C)OC[C@H]1OC(=O)C(O)=C1O[Si](C)(C)C	standard polar	2025-10-24	2244.46
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_6	C[Si](C)(C)OC1=C(O[Si](C)(C)C)[C@@H](CO)OC1=O	standard polar	2025-10-24	2367.43
Gas Chromatography	dehydro-D-arabinono-1,4-lactone_TMS_7	C[Si](C)(C)OC[C@H]1OC(=O)C(O[Si](C)(C)C)=C1O[Si](C)(C)C	standard polar	2025-10-24	2608.06

Biological Properties

Cellular Locations

Not Available

Biospecimen Locations

Not Available

Tissue Locations

Not Available

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Microbial Pathways

Pathways

Not Available

Metabolic Reactions

Reactions

This table shows at most 20 reactions. For the full list of associated reactions:

See All Associated Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Eukaryota/Fungi	Ascomycota	10	Human feces; Human saliva	Unknown

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Std	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference

External Links

HMDB ID

Not Available

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

Not Available

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

C06316

BioCyc ID

CPD-1789

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

54675775

PDB ID

Not Available

ChEBI ID

17803

Food Biomarker Ontology

Not Available

CMMC Knowledgebase

Not Available

General References

Bansal P, Morgat A, Axelsen KB, Muthukrishnan V, Coudert E, Aimo L, Hyka-Nouspikel N, Gasteiger E, Kerhornou A, Neto TB, Pozzato M, Blatter MC, Ignatchenko A, Redaschi N, Bridge A: Rhea, the reaction knowledgebase in 2022. Nucleic Acids Res. 2022 Jan 7;50(D1):D693-D700. doi: 10.1093/nar/gkab1016. [PubMed:34755880 ]

Showing metabocard for dehydro-D-arabinono-1,4-lactone (MMDBc0032944)

MOL for #<Metabolite:0x00007f9ac4076550>

3D MOL for #<Metabolite:0x00007f9ac4076550>

3D SDF for #<Metabolite:0x00007f9ac4076550>

3D-SDF for #<Metabolite:0x00007f9ac4076550>

PDB for #<Metabolite:0x00007f9ac4076550>

3D PDB for #<Metabolite:0x00007f9ac4076550>

SMILES for #<Metabolite:0x00007f9ac4076550>

INCHI for #<Metabolite:0x00007f9ac4076550>

Structure for #<Metabolite:0x00007f9ac4076550>

3D Structure for #<Metabolite:0x00007f9ac4076550>