MiMeDB: Showing metabocard for gamma-Glutamylphenylalanine (MMDBc0000356)

Record Information

Version

1.0

Status

Detected and Quantified

Creation Date

2020-12-10 18:36:01 UTC

Update Date

2024-04-30 19:31:55 UTC

Metabolite ID

MMDBc0000356

Metabolite Identification

Common Name

gamma-Glutamylphenylalanine

Description

gamma-Glutamylphenylalanine is a dipeptide composed of gamma-glutamate and phenylalanine, and is a proteolytic breakdown product of larger proteins. It is probably formed by transpeptidation between glutathione and the corresponding amino acid, catalyzed by gamma-glutamyl transpeptidase (PMID: 237763 ). gamma-Glutamylphenylalanine belongs to the family of N-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid which bears an acyl group at its terminal nitrogen atom. gamma-Glutamylphenylalanine is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. It can be detected in the urine of patients with phenylketonuria, which is a human genetic disorder due to the lack of phenylalanine hydroxylase to metabolize phenylalanine to tyrosine (Wikipedia). gamma-Glutamylphenylalanine is found in adzuki bean, onion (Allium cepa), garlic (Allium sativum), and soybean.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

HMDB0000594
     RDKit          3D
gamma-Glutamylphenylalanine
 39 39  0  0  0  0  0  0  0  0999 V2000
   -5.3415    1.5921    0.0010 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2142    0.6600   -0.2271 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.7848    0.2185    1.1423 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6478   -0.7405    1.1583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4391   -0.1398    0.5901 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4166    1.0594    0.2824 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2897   -0.9339    0.3913 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9118   -0.3496   -0.1703 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9623   -0.4817    0.9275 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2450    0.0697    0.4984 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5270    1.4134    0.6791 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7378    1.9001    0.2801 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6679    1.0748   -0.2933 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3814   -0.2582   -0.4697 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1775   -0.7816   -0.0816 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3239   -1.0513   -1.3880 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6247   -2.0541   -1.7600 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4114   -0.7206   -2.1776 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6716   -0.4845   -1.0531 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8754   -0.5216   -1.3955 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8343   -1.4973   -1.4550 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8318    1.3569    0.8948 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8964    2.5217    0.1343 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3880    1.1992   -0.7160 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5389    1.1781    1.6923 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6733   -0.1730    1.7000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4464   -0.9621    2.2583 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8835   -1.7025    0.6506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2367   -1.9546    0.6282 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6852    0.7296   -0.3617 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5802   -0.0210    1.8560 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0506   -1.5900    1.1185 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8264    2.0835    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9537    2.9660    0.4267 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6373    1.4446   -0.6173 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0930   -0.9433   -0.9203 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9464   -1.8363   -0.2152 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6826    0.2185   -2.4001 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0162   -2.4886   -1.3178 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
  8 16  1  0
 16 17  2  0
 16 18  1  0
  2 19  1  0
 19 20  2  0
 19 21  1  0
 15 10  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  3 25  1  0
  3 26  1  0
  4 27  1  0
  4 28  1  0
  7 29  1  0
  8 30  1  6
  9 31  1  0
  9 32  1  0
 11 33  1  0
 12 34  1  0
 13 35  1  0
 14 36  1  0
 15 37  1  0
 18 38  1  0
 21 39  1  0
M  END


  Mrv1652312011717212D          

 21 21  0  0  0  0            999 V2000
 2498.0793 2500.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2498.7941 2499.9236    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
 2498.7941 2499.0982    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 2499.5109 2498.6845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2500.2257 2499.0982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2500.9405 2498.6845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2501.6552 2499.0982    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
 2502.3700 2498.6845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2503.0847 2499.0982    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2502.3700 2497.8592    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2501.6552 2499.9236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
 2499.5109 2497.8592    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2499.5109 2500.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2500.2257 2499.9236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2499.5109 2501.1606    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
 2497.3649 2499.9231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2496.6505 2500.3354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2495.9361 2499.9230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2495.9360 2499.0981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2496.6504 2498.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
 2497.3649 2499.0982    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  1  0  0  0
  2 13  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4 12  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7 11  1  6  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 16  1  0  0  0  0
  1 16  1  0  0  0  0
M  END
> <DATABASE_ID>
MMDBc0000356

> <DATABASE_NAME>
MIME

> <SMILES>
N[C@@H](CCC(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O)C(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C14H18N2O5/c15-10(13(18)19)6-7-12(17)16-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t10-,11-/m0/s1

> <INCHI_KEY>
XHHOHZPNYFQJKL-QWRGUYRKSA-N

> <FORMULA>
C14H18N2O5

> <MOLECULAR_WEIGHT>
294.3031

> <EXACT_MASS>
294.121571696

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
39

> <JCHEM_AVERAGE_POLARIZABILITY>
29.69671745990118

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
4

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S)-2-amino-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}butanoic acid

> <ALOGPS_LOGP>
-2.15

> <JCHEM_LOGP>
-2.142298981941151

> <ALOGPS_LOGS>
-2.68

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA>
3.933234162481531

> <JCHEM_PKA_STRONGEST_ACIDIC>
1.8172405094101052

> <JCHEM_PKA_STRONGEST_BASIC>
9.312071601125322

> <JCHEM_POLAR_SURFACE_AREA>
129.72

> <JCHEM_REFRACTIVITY>
73.20410000000003

> <JCHEM_ROTATABLE_BOND_COUNT>
8

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.14e-01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
gamma-glutamylphenylalanine

> <JCHEM_VEBER_RULE>
0

$$$$

HMDB0000594
     RDKit          3D
gamma-Glutamylphenylalanine
 39 39  0  0  0  0  0  0  0  0999 V2000
   -5.3415    1.5921    0.0010 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2142    0.6600   -0.2271 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.7848    0.2185    1.1423 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6478   -0.7405    1.1583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4391   -0.1398    0.5901 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4166    1.0594    0.2824 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2897   -0.9339    0.3913 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9118   -0.3496   -0.1703 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9623   -0.4817    0.9275 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2450    0.0697    0.4984 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5270    1.4134    0.6791 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7378    1.9001    0.2801 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6679    1.0748   -0.2933 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3814   -0.2582   -0.4697 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1775   -0.7816   -0.0816 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3239   -1.0513   -1.3880 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6247   -2.0541   -1.7600 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4114   -0.7206   -2.1776 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6716   -0.4845   -1.0531 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8754   -0.5216   -1.3955 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8343   -1.4973   -1.4550 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8318    1.3569    0.8948 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8964    2.5217    0.1343 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3880    1.1992   -0.7160 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5389    1.1781    1.6923 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6733   -0.1730    1.7000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4464   -0.9621    2.2583 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8835   -1.7025    0.6506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2367   -1.9546    0.6282 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6852    0.7296   -0.3617 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5802   -0.0210    1.8560 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0506   -1.5900    1.1185 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8264    2.0835    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9537    2.9660    0.4267 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6373    1.4446   -0.6173 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0930   -0.9433   -0.9203 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9464   -1.8363   -0.2152 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6826    0.2185   -2.4001 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0162   -2.4886   -1.3178 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
  8 16  1  0
 16 17  2  0
 16 18  1  0
  2 19  1  0
 19 20  2  0
 19 21  1  0
 15 10  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  3 25  1  0
  3 26  1  0
  4 27  1  0
  4 28  1  0
  7 29  1  0
  8 30  1  6
  9 31  1  0
  9 32  1  0
 11 33  1  0
 12 34  1  0
 13 35  1  0
 14 36  1  0
 15 37  1  0
 18 38  1  0
 21 39  1  0
M  END

HEADER    PROTEIN                                 01-DEC-17   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   01-DEC-17         0                                  
HETATM    1  C   UNK     0    4663.0814667.293   0.000  0.00  0.00           C+0
HETATM    2  C   UNK     0    4664.4164666.524   0.000  0.00  0.00           C+0
HETATM    3  N   UNK     0    4664.4164664.983   0.000  0.00  0.00           N+0
HETATM    4  C   UNK     0    4665.7544664.211   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0    4667.0884664.983   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0    4668.4224664.211   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0    4669.7564664.983   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0    4671.0914664.211   0.000  0.00  0.00           C+0
HETATM    9  O   UNK     0    4672.4254664.983   0.000  0.00  0.00           O+0
HETATM   10  O   UNK     0    4671.0914662.671   0.000  0.00  0.00           O+0
HETATM   11  N   UNK     0    4669.7564666.524   0.000  0.00  0.00           N+0
HETATM   12  O   UNK     0    4665.7544662.671   0.000  0.00  0.00           O+0
HETATM   13  C   UNK     0    4665.7544667.293   0.000  0.00  0.00           C+0
HETATM   14  O   UNK     0    4667.0884666.524   0.000  0.00  0.00           O+0
HETATM   15  O   UNK     0    4665.7544668.833   0.000  0.00  0.00           O+0
HETATM   16  C   UNK     0    4661.7484666.523   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0    4660.4144667.293   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0    4659.0814666.523   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0    4659.0814664.983   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0    4660.4144664.213   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0    4661.7484664.983   0.000  0.00  0.00           C+0
CONECT    1    2   16                                                       
CONECT    2    1    3   13                                                  
CONECT    3    2    4                                                       
CONECT    4    3    5   12                                                  
CONECT    5    4    6                                                       
CONECT    6    5    7                                                       
CONECT    7    6    8   11                                                  
CONECT    8    7    9   10                                                  
CONECT    9    8                                                            
CONECT   10    8                                                            
CONECT   11    7                                                            
CONECT   12    4                                                            
CONECT   13    2   14   15                                                  
CONECT   14   13                                                            
CONECT   15   13                                                            
CONECT   16   17   21    1                                                  
CONECT   17   16   18                                                       
CONECT   18   17   19                                                       
CONECT   19   18   20                                                       
CONECT   20   19   21                                                       
CONECT   21   20   16                                                       
MASTER        0    0    0    0    0    0    0    0   21    0   42    0
END

COMPND    HMDB0000594
HETATM    1  N1  UNL     1      -5.342   1.592   0.001  1.00  0.00           N  
HETATM    2  C1  UNL     1      -4.214   0.660  -0.227  1.00  0.00           C  
HETATM    3  C2  UNL     1      -3.785   0.218   1.142  1.00  0.00           C  
HETATM    4  C3  UNL     1      -2.648  -0.741   1.158  1.00  0.00           C  
HETATM    5  C4  UNL     1      -1.439  -0.140   0.590  1.00  0.00           C  
HETATM    6  O1  UNL     1      -1.417   1.059   0.282  1.00  0.00           O  
HETATM    7  N2  UNL     1      -0.290  -0.934   0.391  1.00  0.00           N  
HETATM    8  C5  UNL     1       0.912  -0.350  -0.170  1.00  0.00           C  
HETATM    9  C6  UNL     1       1.962  -0.482   0.928  1.00  0.00           C  
HETATM   10  C7  UNL     1       3.245   0.070   0.498  1.00  0.00           C  
HETATM   11  C8  UNL     1       3.527   1.413   0.679  1.00  0.00           C  
HETATM   12  C9  UNL     1       4.738   1.900   0.280  1.00  0.00           C  
HETATM   13  C10 UNL     1       5.668   1.075  -0.293  1.00  0.00           C  
HETATM   14  C11 UNL     1       5.381  -0.258  -0.470  1.00  0.00           C  
HETATM   15  C12 UNL     1       4.178  -0.782  -0.082  1.00  0.00           C  
HETATM   16  C13 UNL     1       1.324  -1.051  -1.388  1.00  0.00           C  
HETATM   17  O2  UNL     1       0.625  -2.054  -1.760  1.00  0.00           O  
HETATM   18  O3  UNL     1       2.411  -0.721  -2.178  1.00  0.00           O  
HETATM   19  C14 UNL     1      -4.672  -0.484  -1.053  1.00  0.00           C  
HETATM   20  O4  UNL     1      -5.875  -0.522  -1.396  1.00  0.00           O  
HETATM   21  O5  UNL     1      -3.834  -1.497  -1.455  1.00  0.00           O  
HETATM   22  H1  UNL     1      -5.832   1.357   0.895  1.00  0.00           H  
HETATM   23  H2  UNL     1      -4.896   2.522   0.134  1.00  0.00           H  
HETATM   24  H3  UNL     1      -3.388   1.199  -0.716  1.00  0.00           H  
HETATM   25  H4  UNL     1      -3.539   1.178   1.692  1.00  0.00           H  
HETATM   26  H5  UNL     1      -4.673  -0.173   1.700  1.00  0.00           H  
HETATM   27  H6  UNL     1      -2.446  -0.962   2.258  1.00  0.00           H  
HETATM   28  H7  UNL     1      -2.884  -1.703   0.651  1.00  0.00           H  
HETATM   29  H8  UNL     1      -0.237  -1.955   0.628  1.00  0.00           H  
HETATM   30  H9  UNL     1       0.685   0.730  -0.362  1.00  0.00           H  
HETATM   31  H10 UNL     1       1.580  -0.021   1.856  1.00  0.00           H  
HETATM   32  H11 UNL     1       2.051  -1.590   1.118  1.00  0.00           H  
HETATM   33  H12 UNL     1       2.826   2.083   1.122  1.00  0.00           H  
HETATM   34  H13 UNL     1       4.954   2.966   0.427  1.00  0.00           H  
HETATM   35  H14 UNL     1       6.637   1.445  -0.617  1.00  0.00           H  
HETATM   36  H15 UNL     1       6.093  -0.943  -0.920  1.00  0.00           H  
HETATM   37  H16 UNL     1       3.946  -1.836  -0.215  1.00  0.00           H  
HETATM   38  H17 UNL     1       2.683   0.218  -2.400  1.00  0.00           H  
HETATM   39  H18 UNL     1      -4.016  -2.489  -1.318  1.00  0.00           H  
CONECT    1    2   22   23
CONECT    2    3   19   24
CONECT    3    4   25   26
CONECT    4    5   27   28
CONECT    5    6    6    7
CONECT    7    8   29
CONECT    8    9   16   30
CONECT    9   10   31   32
CONECT   10   11   11   15
CONECT   11   12   33
CONECT   12   13   13   34
CONECT   13   14   35
CONECT   14   15   15   36
CONECT   15   37
CONECT   16   17   17   18
CONECT   18   38
CONECT   19   20   20   21
CONECT   21   39
END

HMDB0000594
     RDKit          3D
gamma-Glutamylphenylalanine
 39 39  0  0  0  0  0  0  0  0999 V2000
   -5.3415    1.5921    0.0010 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2142    0.6600   -0.2271 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.7848    0.2185    1.1423 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6478   -0.7405    1.1583 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4391   -0.1398    0.5901 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4166    1.0594    0.2824 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2897   -0.9339    0.3913 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9118   -0.3496   -0.1703 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9623   -0.4817    0.9275 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2450    0.0697    0.4984 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5270    1.4134    0.6791 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7378    1.9001    0.2801 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6679    1.0748   -0.2933 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3814   -0.2582   -0.4697 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1775   -0.7816   -0.0816 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3239   -1.0513   -1.3880 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6247   -2.0541   -1.7600 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4114   -0.7206   -2.1776 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6716   -0.4845   -1.0531 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8754   -0.5216   -1.3955 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8343   -1.4973   -1.4550 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8318    1.3569    0.8948 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8964    2.5217    0.1343 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3880    1.1992   -0.7160 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5389    1.1781    1.6923 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6733   -0.1730    1.7000 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4464   -0.9621    2.2583 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8835   -1.7025    0.6506 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2367   -1.9546    0.6282 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6852    0.7296   -0.3617 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.5802   -0.0210    1.8560 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.0506   -1.5900    1.1185 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.8264    2.0835    1.1218 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9537    2.9660    0.4267 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.6373    1.4446   -0.6173 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.0930   -0.9433   -0.9203 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.9464   -1.8363   -0.2152 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.6826    0.2185   -2.4001 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0162   -2.4886   -1.3178 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  2  0
  5  7  1  0
  7  8  1  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 14 15  2  0
  8 16  1  0
 16 17  2  0
 16 18  1  0
  2 19  1  0
 19 20  2  0
 19 21  1  0
 15 10  1  0
  1 22  1  0
  1 23  1  0
  2 24  1  6
  3 25  1  0
  3 26  1  0
  4 27  1  0
  4 28  1  0
  7 29  1  0
  8 30  1  6
  9 31  1  0
  9 32  1  0
 11 33  1  0
 12 34  1  0
 13 35  1  0
 14 36  1  0
 15 37  1  0
 18 38  1  0
 21 39  1  0
M  END

Synonyms

Value	Source
(2S)-2-Amino-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}butanoic acid	ChEBI
L-gamma-Glu-L-phe	ChEBI
L-gamma-Glutamyl-L-phenylalanine	ChEBI
N-(gamma-L-Glutamyl)phenylalanine	ChEBI
N-L-gamma-Glutamyl-3-phenyl-L-alanine	ChEBI
N-L-gamma-Glutamyl-L-phenylalanine	ChEBI
(2S)-2-Amino-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}butanoate	Generator
L-g-Glu-L-phe	Generator
L-Γ-glu-L-phe	Generator
L-g-Glutamyl-L-phenylalanine	Generator
L-Γ-glutamyl-L-phenylalanine	Generator
N-(g-L-Glutamyl)phenylalanine	Generator
N-(Γ-L-glutamyl)phenylalanine	Generator
N-L-g-Glutamyl-3-phenyl-L-alanine	Generator
N-L-Γ-glutamyl-3-phenyl-L-alanine	Generator
N-L-g-Glutamyl-L-phenylalanine	Generator
N-L-Γ-glutamyl-L-phenylalanine	Generator
g-Glutamylphenylalanine	Generator
Γ-glutamylphenylalanine	Generator
gamma-Glu-phe	MeSH
γ-Glu-Phe	HMDB, Generator
γ-L-Glu-L-Phe	HMDB
γ-L-Glutamyl-L-phenylalanine	HMDB
N-γ-Glutamylphenylalanine	HMDB
N-L-γ-Glutamylphenylalanine	HMDB
gamma-L-Glu-L-Phe	HMDB
gamma-L-Glutamyl-L-phenylalanine	HMDB
N-gamma-Glutamylphenylalanine	HMDB
N-L-gamma-Glutamylphenylalanine	HMDB
H-γ-Glu-Phe-OH	HMDB
H-gamma-Glu-Phe-OH	HMDB
gamma-Glutamylphenylalanine	HMDB, ChEBI
N-gamma-L-Glutamyl-L-phenylalanine	HMDB
N-γ-L-Glutamyl-L-phenylalanine	HMDB
g-Glu-Phe	Generator, HMDB

Molecular Formula

C₁₄H₁₈N₂O₅

Average Mass

294.3031

Monoisotopic Mass

294.121571696

IUPAC Name

(2S)-2-amino-4-{[(1S)-1-carboxy-2-phenylethyl]carbamoyl}butanoic acid

Traditional Name

gamma-glutamylphenylalanine

CAS Registry Number

Not Available

SMILES

N[C@@H](CCC(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O)C(O)=O

InChI Identifier

InChI=1S/C14H18N2O5/c15-10(13(18)19)6-7-12(17)16-11(14(20)21)8-9-4-2-1-3-5-9/h1-5,10-11H,6-8,15H2,(H,16,17)(H,18,19)(H,20,21)/t10-,11-/m0/s1

InChI Key

XHHOHZPNYFQJKL-QWRGUYRKSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phenylalanine and derivatives. Phenylalanine and derivatives are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Phenylalanine and derivatives

Alternative Parents

Substituents

Phenylalanine or derivatives
N-acyl-alpha-amino acid
N-acyl-alpha amino acid or derivatives
3-phenylpropanoic-acid
Alpha-amino acid
Amphetamine or derivatives
L-alpha-amino acid
Monocyclic benzene moiety
Benzenoid
Dicarboxylic acid or derivatives
Amino acid
Carboximidic acid
Carboximidic acid derivative
Organic 1,3-dipolar compound
Propargyl-type 1,3-dipolar organic compound
Carboxylic acid
Organic nitrogen compound
Organonitrogen compound
Primary aliphatic amine
Organooxygen compound
Primary amine
Hydrocarbon derivative
Organic oxide
Carbonyl group
Organopnictogen compound
Organic oxygen compound
Amine
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

Not Available

Functional Ontology

Not Available

Physical Properties

State

Expected Solid

Predicted Properties

Property	Value	Source
Water Solubility	0.61 g/L	ALOGPS
logP	-2.2	ALOGPS
logP	-2.1	ChemAxon
logS	-2.7	ALOGPS
pKa (Strongest Acidic)	1.82	ChemAxon
pKa (Strongest Basic)	9.31	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	129.72 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	73.2 m³·mol⁻¹	ChemAxon
Polarizability	29.7 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Not Available

Biological Properties

Cellular Locations

Cytoplasm

Biospecimen Locations

Blood
Feces
Kidney
Placenta
Urine

Tissue Locations

Kidney
Placenta

Associated OMIM IDs

114500 (Colorectal cancer)
610247 (Eosinophilic esophagitis)

Human Proteins and Enzymes

Protein ID	Protein Name	Protein Type	Uniprot ID	Species

Human Pathways

Pathways

Name	SMPDB/PathBank

Metabolic Reactions

Reactions

Reaction ID	Precursor	Product	Enzyme	Reaction Type	Data Source	Reference

Health Effects and Bioactivity

Health Outcome/Bioactivity	Metabolite Response/Effect	Evidence Type	Host and Biospecimen	Data Source	Reference
Phenylketonuria		Association	Human Urine	HMDB	466810

Microbial Sources

Superkingdom/Kingdom	Phylum	Total species	Hosts and Body Sites	Microbial Links
Bacteria/Eubacteria	Bacteroidetes	1	Human feces; Human stool; Human	Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteria/Eubacteria	Firmicutes	8	Human stool; Human ; Human feces	Indirect association between microbiota composition and metabolites measured in host biospecimen
Bacteria/Eubacteria	Actinobacteria	1	Human ; Human feces; Human sputum; Human saliva; Human supragingival plaque; Human subgingival plaque	Indirect association between microbiota composition and metabolites measured in host biospecimen

Exposure Sources

Other Exposures

Source Type	Data Source	Reference

Host Biospecimen and Location

Host and Biospecimen	Status	Mean	Min	Max	Units	Age	Sex	Health Condition	Data Source	Reference
Human Urine	Detected and Quantified	43.00	8.00	78.00	umol/mmol creatinine	Newborn (0-30 days old)	Both	Phenylketonuria	HMDB	466810
Human Kidney	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597
Human Placenta	Detected but not Quantified					Not Specified	Not Specified	Normal	HMDB	34986597
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	27543620
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	25037050
Human Feces	Detected but not Quantified					Adult (>18 years old)	Both	Normal	HMDB	29808030
Human Blood	Detected but not Quantified								HMDB

External Links

HMDB ID

HMDB0029562

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB112161

KNApSAcK ID

Not Available

Chemspider ID

99868

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

111299

PDB ID

Not Available

ChEBI ID

89582

Food Biomarker Ontology

Not Available

References

Synthesis Reference

Not Available

General References

Orlowski M, Wilk S: Intermediates of the gamma-glutamyl cycle in mouse tissues. Influence of administration of amino acids on pyrrolidone carboxylate and gamma-glutamyl amino acids. Eur J Biochem. 1975 May 6;53(2):581-90. doi: 10.1111/j.1432-1033.1975.tb04101.x. [PubMed:237763 ]
Peck H, Pollitt RJ: The occurrence of gamma-glutamylphenylalanine in the urine of newborn phenylketonurics. Clin Chim Acta. 1979 Jun 15;94(3):237-40. doi: 10.1016/0009-8981(79)90070-6. [PubMed:466810 ]
Jandke J, Spiteller G: Dipeptide analysis in human urine. J Chromatogr. 1986 Oct 31;382:39-45. doi: 10.1016/s0378-4347(00)83502-1. [PubMed:3782411 ]
Bridges RJ, Meister A: gamma-Glutamyl amino acids. Transport and conversion to 5-oxoproline in the kidney. J Biol Chem. 1985 Jun 25;260(12):7304-8. [PubMed:3997870 ]
Kamerling JP, Aarsen GJ, Duran M, de Bree PK, van Sprang FJ, Wadman SK: Chromatographic determination and mass spectrometric identification of gamma-glutamylphenylalanine, a urinary constituent in phenylketonuria. Clin Chim Acta. 1980 Mar 28;102(2-3):137-45. doi: 10.1016/0009-8981(80)90026-1. [PubMed:7371187 ]
Lawson LD, Gardner CD: Composition, stability, and bioavailability of garlic products used in a clinical trial. J Agric Food Chem. 2005 Aug 10;53(16):6254-61. doi: 10.1021/jf050536+. [PubMed:16076102 ]
Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
Yannai, Shmuel (2004). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. Boca Raton: Chapman & Hall/CRC..

Showing metabocard for gamma-Glutamylphenylalanine (MMDBc0000356)

MOL for #<Metabolite:0x00007f91c1d3beb8>

3D MOL for #<Metabolite:0x00007f91c1d3beb8>

3D SDF for #<Metabolite:0x00007f91c1d3beb8>

3D-SDF for #<Metabolite:0x00007f91c1d3beb8>

PDB for #<Metabolite:0x00007f91c1d3beb8>

3D PDB for #<Metabolite:0x00007f91c1d3beb8>

SMILES for #<Metabolite:0x00007f91c1d3beb8>

INCHI for #<Metabolite:0x00007f91c1d3beb8>

Structure for #<Metabolite:0x00007f91c1d3beb8>

3D Structure for #<Metabolite:0x00007f91c1d3beb8>